Association study of PICKI rs3952 polymorphism and schizophrenia
Association study of PICKI rs3952 polymorphism and schizophrenia
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DOI：
10.1097/00001756-200408260-00026
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发表时间：
2004-08-26
期刊：
影响因子：
1.7
通讯作者：
Tsai, SJ
中科院分区：
文献类型：
--
作者：
Hong, CJ;Liao, DL;Tsai, SJ
与C-激酶-I相互作用的蛋白质（PICKI）在神经元受体和胺转运体的靶向和聚集中起着重要作用。PICKI基因可能在赋予精神分裂症易感性方面发挥作用，因为它已被定位于染色体22q13.1，该区域被认为含有精神分裂症基因。我们检验了PICKI基因的等位基因变异与精神分裂症诊断相关的假设。对225例精神分裂症患者和260例对照者进行PICKI rs3952多态性基因分型。结果表明，两组PICKI rs3952基因型和等位基因分布差异有统计学意义。PICKI基因可能在精神分裂症的发病机制中起一定作用。
Protein interacting with C-kinase-I (PICKI) plays an important role in the targeting and clustering of neuronal receptors and amine transporters. The PICKI gene may play a role in conferring susceptibility to schizophrenia as it has been mapped to chromosome 22q13.1, a region thought to contain a gene for schizophrenia. We tested the hypothesis that an allelic variant of the PICKI gene was associated with a diagnosis of schizophrenia. The PICKI rs3952 polymorphism was genotyped in 225 schizophrenia and 260 controls. Results demonstrated that the PICKI rs3952 genotype and allele distribution was significantly different between the two groups. The positive association suggests that the PICKI gene may play a role in the pathogenesis of schizophrenia.