DOWNS-SYNDROME IN SAUDI-ARABIA - INCIDENCE AND CYTOGENETICS
DOWNS-SYNDROME IN SAUDI-ARABIA - INCIDENCE AND CYTOGENETICS
复制标题
DOI：
10.1159/000154261
复制
发表时间：
1995-03-01
期刊：
影响因子：
1.8
通讯作者：
ALEISSA, YA
中科院分区：
文献类型：
--
作者：
NIAZI, MA;ALMAZYAD, AS;ALEISSA, YA
在利雅得进行了一项研究，以确定1982年7月至1991年6月9年期间唐氏综合症新生儿的发病率和分布情况。在沙特妇女连续活产的23，261名婴儿中，有42名（23名女性和19名男性）被确定患有唐氏综合症，发病率为每554名活产婴儿中有1名（每1，000名婴儿中有1.8名）。唐氏综合征的发病率增加的趋势与先进的产妇年龄或增加产妇paradise被发现。细胞遗传学研究进行了37例，其中所有的，但1个是非分离三体21，而其余的婴儿有易位。这项研究为进一步在沙特阿拉伯王国进行唐氏综合症流行病学调查迈出了第一步，以便为有效的产前染色体疾病筛查方案奠定基础。
A study has been carried out in Riyadh to determine the incidence and distribution of Down's syndrome births during a 9-year period from July 1982 to June 1991. Down's syndrome was ascertained in 42 (23 females and 19 males) of 23,261 consecutive babies born alive to Saudi women, giving an incidence of 1 in 554 live births (1.8 per 1,000). A trend towards an increased incidence of Down's syndrome with advanced maternal age or increased maternal parity was found. Cytogenetic studies were performed on 37 cases of which all but 1 were non-disjunction trisomy 21, while the remaining infant had a translocation. This study provides the first step for further epidemiological surveys of Down's syndrome in the Kingdom of Saudi Arabia in order to prepare the ground for an effective antenatal screening programme for chromosomal disorders.