The role of FSH in the selection of large ovarian follicles in the rat.
The role of FSH in the selection of large ovarian follicles in the rat.
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FSH 在大鼠大卵泡选择中的作用。
DOI：
10.1095/biolreprod19.3.606
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发表时间：
1978
影响因子：
3.6
通讯作者：
A. Midgley
中科院分区：
文献类型：
--
作者：
A. Hirshfield;A. Midgley
为了确定FSH的排卵前高峰是否在随后的发情周期中选择一组预定排卵的卵泡，在发情前期的前一天注射外源性FSH，并在24小时后对卵巢进行组织学和形态计量学检查。在内源性促性腺激素激增的前一天注射外源性FSH导致一群小的Graafian前卵泡(直径390-500 pm)比通常出现的时间提前一天出现。消除发情前期的卵泡刺激素/黄体生成素峰值。通过巴比妥酸盐阻断促性腺激素的激增。防止了通常在发情期出现的格拉菲亚前小卵泡的涌入。然而，在巴比妥酸盐阻断的动物中，替换FSH可以恢复这些小的格拉菲亚前卵泡的外观。这些结果表明，一个周期的FSH激增可能会挽救200-400 PM大小的卵泡，从而选择那些将在下一个周期排卵的卵泡。
To determine if the preovulatory surge of FSH plays a role in the selection of a cohort of follicles destined so ovulate during the subsequent estrous cycle, exogenous FSH was administered on the day before proestrus and the ovaries were examined 24 h later using histological and morphometric techniques. Administration of exogenous FSH I day ahead of she endogenous surge of gonadotropins caused the appearance of a cohort of small pre-Graafian follicles (390-500 pm in diameter) I day ahead of the time of their usual appearance. Elimination of the FSH / LH surge on proestrus. by means of a barbiturate blockade of the surge of gonadotropins. prevented the influx of small pre-Graafian follicles normally seen on estrus. However, replacement of FSH in barbiturate blocked animals restored the appearance of these small pre-Graafian follicles. These results suggest that the FSH surge of one cycle may rescue follicles in the 200-400 pm size range, thereby selecting those follicles which will ovulate during the next cycle.