Organization and development of the brain stem auditory nuclei of the chicken: Primary afferent projections
Organization and development of the brain stem auditory nuclei of the chicken: Primary afferent projections
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鸡脑干听觉核团的组织和发育：初级传入投射
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
E. Rubel
中科院分区：
文献类型：
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作者：
T. Parks;E. Rubel
用终末变性法和辣根过氧化物酶（HRP）或氚化氨基酸顺行转运法研究了雏鸡脑干初级听觉投射的类型。特别令人感兴趣的问题是，核层（NL）是否接受初级传入。单侧耳蜗神经中断后，对大细胞核（NM）和NL中三个时间间隔的银染变性模式进行了研究，结果显示，到损伤后48小时，仅在同侧角状核（NA）、NM和拉格纳投射区发现变性终末，但在NL中未发现。然而，5天和8天的生存时间也显示NL双侧变性。在较长的生存时间内NL中出现终末变性是由于先前报告的传入神经阻滞后NM中神经元的严重和快速跨神经元变性，而不是NL中耳蜗神经终末的存在。将HRP或氚化脯氨酸注射到基底乳头中产生的标记模式与在2天变性材料中观察到的标记模式相似; HRP反应产物或放射自显影标记仅见于同侧NA和NM以及同侧黄斑投射区，但未见于任何NL。三种方法揭示的初级听觉投射的模式彼此非常相似，与先前报道的鸽子相似，证实了鸡的板状核不接受初级传入的结论。
The pattern of primary auditory projections to the brain stem of young chickens was investigated using terminal degeneration methods and orthograde transport of horseradish peroxidase (HRP) or tritiated amino acid. Of particular interest was the question of whether nucleus laminaris (NL) receives primary afferents. A study of silver‐stained degeneration patterns in nucleus magnocellularis (NM) and NL at three intervals following unilateral interruption of the cochlear nerve revealed that by 48 hours after the lesion, degenerating terminals were found only in the ipsilateral nucleus angularis (NA), NM and lagenar projection areas but not in NL. Five‐ and eight‐day survival times, however, also revealed degeneration bilaterally in NL. The appearance of terminal degeneration in NL at the longer survival times is attributed to the previously‐reported severe and rapid transneuronal degeneration of neurons in NM following deafferentation and not to the presence of cochlear nerve terminals in NL. Injection of HRP or tritiated proline into the basilar papilla produced patterns of labeling similar to that seen in the 2‐day degeneration material; HRP reaction product or autoradiographic label were seen only in the ipsilateral NA and NM and in the ipsilateral projection areas of the macula lagena but not in either NL. The patterns of primary auditory projections revealed by the three methods were quite similar to each other and to that previously reported for the pigeon and confirm the conclusion that the laminar nucleus of chickens does not receive primary afferents.