CANINE-DISTEMPER ENCEPHALOMYELITIS - VARIATION WITH VIRUS-STRAIN
CANINE-DISTEMPER ENCEPHALOMYELITIS - VARIATION WITH VIRUS-STRAIN
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DOI：
10.1016/0021-9975(84)90009-4
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发表时间：
1984-01-01
影响因子：
0.8
通讯作者：
APPEL, MJG
中科院分区：
文献类型：
--
作者：
SUMMERS, BA;GREISEN, HA;APPEL, MJG
比较了犬瘟热病毒（CDV）3个强毒株在无特定病原体Beagle犬体内的致病性。所有菌株均产生脑脊髓炎;观察到严重程度、临床病程和导致的神经病理学变化。犬瘟热病毒的Snyder Hill毒株感染持续为急性;犬在接种后14-19天死亡（PI）或恢复。脊髓损伤是脊髓灰质炎脑脊髓炎。CDV株A75-17产生亚急性至慢性疾病，其中脱髓鞘是主要发现。一些犬死亡，通常在PI约28-42天。该组中的一些成员再次记录到完全恢复。其他患者出现持续性CNS感染，但在临床上保持稳定，直至用巴比妥类药物选择性处死，持续至PI 62天。CDV毒株R252也诱导迟发性、主要为白色物质的疾病，具有死亡、持续感染和恢复的混合模式，类似于A75-17。中和抗体反应与病程相关。死亡的犬血清滴度低或缺乏血清抗体。恢复期犬的滴度最早且最高。少数持续CNS感染的犬CSF中也有抗体。目前的概念犬瘟热脑脊髓炎（CDE）的发病机制进行了讨论，并提出了CDE的应变依赖性的临床和病理表现的基础。病毒株似乎是这种犬CNS常见疾病的重要因素。
Disease induced by 3 virulent strains of canine distemper virus (CDV) was compared in specific pathogen-free Beagle dogs. All strains produced an encephalomyelitis; variation was observed in the severity, clinical course and resulting neuropathology. Infection with Snyder Hill strian fo CDV was consistently acute; dogs succumbed 14-19 day post-inoculation (PI) or recovered. Lesions in the neuraxis were those of a polioencephalomyelitis. CDV strain A75-17 produced subacute to chronic disease in which demyelination was the predominant finding. Some dogs succumbed, generally around 28-42 days PI. Total recovery was again recorded for some members of the group. Others developed persistent CNS infection but remained clinically stable until electively killed with barbiturate, up to 62 days PI. CDV strain R252 also induced delayed, predominantly white matter disease with a mixed pattern of mortalities, persistent infections and recoveries, similar to A75-17. Neutralizing antibody responses correlated with the disease course. Dogs which died had low serum titers or lacked serum antibody. Recovering dogs had the earliest and highest titers. A few dogs with persistent CNS infection had antibody in the CSF also. Current concepts of the pathogenesis of canine distemper encephalomyelitis (CDE) are discussed and a basis for the strain-dependent clinical and pathological expression of CDE is proposed. Viral strain appears to be an important factor in this common disease of the canine CNS.