URINARY CALCIUM, SODIUM AND BONE MASS OF YOUNG FEMALES
URINARY CALCIUM, SODIUM AND BONE MASS OF YOUNG FEMALES
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DOI：
10.1093/ajcn/62.2.417
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发表时间：
1995-08-01
影响因子：
7.1
通讯作者：
GOEL, PK
中科院分区：
文献类型：
--
作者：
MATKOVIC, V;ILICH, JZ;GOEL, PK
钙是青年人峰值骨量的重要决定因素，因为它影响生长过程中的骨骼发育。达到最大峰值骨量需要钙摄入量和钙的强制性损失（主要是尿液和粪便中的钙）之间的最佳正平衡。尿排泄是钙在体内滞留的重要决定因素。因此，本研究的目的是评估各种营养素对尿钙排泄的影响，并评估它们对青春期早期8-13岁年轻女性骨量的影响。该研究在381名青春期2期健康白色女性中进行。从每个参与者，我们收集了基本的人体测量数据，三维食物记录，血液，24小时尿样，并通过双能X射线吸收法测量全身和前臂的骨量。尿钠是影响尿钙排泄的重要因素之一：[尿钙（mmol/d）= 0.01154 ×尿钠（mmol/d）+ 0.823]，而钙摄入量的影响相对较小：[尿钙（mmol/d）= 0.02252 ×钙摄入量（mmol/d）+ 1.5261]。当钙摄入量接近37.5 mmol/d（1500 mg/d）时，尿钙要高得多，支持钙是阈值营养素的观点。钙的摄入量有显着的积极影响，骨矿物质含量和密度的整个身体和桡骨干，而尿钙有负面影响，可能是通过减少钙沉积到骨骼。低钙摄入和尿中相对高的强制性钙丢失，在快速生长期间钠摄入加强，可能会减少骨骼中的钙潴留，伴随着峰值骨量的减少。这项研究的结果表明，青少年的钙需要量可能会受到钠摄入量的影响。
Calcium is an important determinant of peak bone mass in young adults because of its influence on skeletal development during growth. Attainment of maximum peak bone mass requires optimal positive balance between calcium intake and obligatory losses of calcium, primarily in urine and feces. Urinary excretion is an important determinant of calcium retention in the body. Accordingly, the purpose of this study was to evaluate the influence of various nutrients on urinary calcium excretion, and to assess their impact on bone mass of young females, aged 8-13 y, during early puberty. The study was conducted in 381 healthy white females in pubertal stage 2. From each participant we collected basic anthropometric measurements, a 3-d food record, blood, a 24-h urine sample, and bone mass measurements of the total body and forearm by dual X-ray absorptiometry. Urinary sodium was found to be one of the most important determinants of urinary calcium excretion: [urinary calcium (mmol/d) = 0.01154 X urinary sodium (mmol/d) + 0.823], whereas calcium intake had relatively little impact: [urinary calcium (mmol/d) = 0.02252 X calcium intake (mmol/d) + 1.5261]. Urinary calcium was much higher at a calcium intake of approximate to 37.5 mmol/d (1500 mg/d), supporting the notion that calcium is a threshold nutrient. Calcium intake had a significant positive influence on the bone mineral content and density of the whole body and radius shaft whereas urinary calcium had a negative influence, presumably by reducing calcium accretion into the skeleton. Low calcium intake and relatively high obligatory calcium loss in the urine, potentiated by sodium intake during rapid growth, may reduce calcium retention in the skeleton with a concomitant reduction in peak bone mass. The results of this study suggest that the calcium requirement for adolescents may be influenced by sodium intake.