Ambulatory blood pressure monitoring and risk of cardiovascular disease: A population based study
Ambulatory blood pressure monitoring and risk of cardiovascular disease: A population based study
复制标题
DOI：
10.1016/j.amjhyper.2005.09.018
复制
发表时间：
2006-03-01
影响因子：
3.2
通讯作者：
Torp-Pedersen, C
中科院分区：
文献类型：
--
作者：
Hansen, TW;Jeppesen, J;Torp-Pedersen, C
背景资料：动态血压（BP）和心血管疾病之间的关系在一般population.Methods：前瞻性研究随机抽样的1700丹麦男性和女性，年龄在41至72岁，没有重大心血管疾病的信息是稀疏的。在基线时，记录动态血压，办公室血压和其他危险因素。终点是一个联合终点，包括心血管死亡率、缺血性心脏病和中风。结果：经过平均9.5年的随访，记录了156个终点。在多变量模型中，与动态收缩压/舒张压增加10/5 mmHg相关的相对风险（95%置信区间）为1.35（1.21-1.50）和1.27（1.16-1.39）。办公室血压的相应数字为1.18（1.09-1.29）和1.11（1.03-1.19）。与血压正常者（诊室血压= 140/90 mm Hg;白天血压≥ 135/85 mm Hg）相比，分别为0.66（0.30-1.44）、1.52（0.91-2.54）和2.10（1.45-3.06）。夜间血压下降不明显是白天动态高血压患者的危险因素（P = 0.02），而不是白天动态血压正常者（P = 0.13.Conclusions：动态血压比诊室血压更能提供心血管疾病的预后信息。单纯的办公室高血压不是危险因素，单纯的动态高血压往往与风险增加有关。夜间血压下降缓慢是白天动态高血压患者的一个危险因素。
Background: Information on the relationship between ambulatory blood pressure (BP) and cardiovascular disease in the general population is sparse.Methods: Prospective study of a random sample of 1700 Danish men and women, aged 41 to 72 years, without major cardiovascular diseases. At baseline, ambulatory BP, office BP, and other risk factors were recorded. The end point was a combined end point consisting of cardiovascular mortality, ischemic heart disease, and stroke.Results: After a mean follow-up of 9.5 years, 156 end points were recorded. In multivariate models, the relative risk (95% confidence interval) associated with increments of 10/5 mmHg of systolic/diastolic ambulatory BP were 1.35 (1.21-1.50) and 1.27 (1.16-1.39). The corresponding figures for office BP were 1.18 (1.09-1.29) and 1.11 (1.03-1.19). Compared with normotension (office BP = 140/90 mm Hg; daytime BP >= 135/85 mm Hg) were 0.66 (0.30-1.44), 1.52 (0.91-2.54), and 2.10 (1.45-3.06), respectively. A blunted BP decrease at night was a risk factor (P =.02) in subjects with daytime ambulatory hypertension, but not in subjects with daytime ambulatory normotension (P =.13).Conclusions: Ambulatory BP provided prognostic information about cardiovascular disease better than office BP. Isolated office hypertension was not a risk factor and isolated ambulatory hypertension tended to be associated with increased risk. A blunted BP decrease at night was a risk factor in subjects with daytime ambulatory hypertension.