Isobolographic analysis of interactions: An update on applications and utility
Isobolographic analysis of interactions: An update on applications and utility
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DOI：
10.1016/0300-483x(95)03210-7
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发表时间：
1995-12-28
期刊：
影响因子：
4.5
通讯作者：
Gessner, PK
中科院分区：
文献类型：
--
作者：
Gessner, PK
等位相图分析为评估混合制剂引起的生物反应是否大于、等于或小于根据组成制剂的单独活性和剂量可加性概念而预期的提供了基本依据。等谱分析仅限于对二元混合物的直接应用，它为分析三元混合物和高阶混合物的相互作用提供了一个概念框架和一个明确的术语，以及一个代数范例。提供了大量图解说明的例证，以促进对该方法的理解，并为不熟悉该方法的调查人员提供指南。讨论了等效线的理论推导，各种剂量组合的表示，剂量可加性、超可加性、次可加性、拮抗性原理的推导，混合效价的概率分析方法，效应相加和峰效应符合的时间或不及时的后果，以及等效分析在剂量-效应曲面法各个方面的作用。
Isobolographic analysis provides a fundamental basis for assessing whether biological responses induced by mixtures of agents are greater, equal or smaller than would have been expected on the basis of the individual activities of the component agents and the concept of dose additivity. Limited in its direct application to binary mixtures, isobolographic analysis provides a conceptual framework and an unambiguous terminology, as well as an algebraic paradigm for the analysis of the interaction of ternary and higher order mixtures. A library of examples generously illustrated graphically is provided to facilitate the understanding of the methodology and serve as a guide for investigators who are unfamiliar with the approach. Also discussed are the theoretical derivation of the isobologram, the representation of various dosage combinations, the derivation of the principle of dose additivity, supra-additivity, infra-additivity, antagonism, the methods for probit analysis of mixture potency, effect addition and the consequences of peak effect coincidence in time or lack thereof, and the role of isobolographic analysis in the various aspects of dose-response surface methodology.