NUCLEAR MAGNETIC-RESONANCE IMAGING OF ACUTE MYOCARDIAL-INFARCTION IN DOGS - ALTERATIONS IN MAGNETIC-RELAXATION TIMES
NUCLEAR MAGNETIC-RESONANCE IMAGING OF ACUTE MYOCARDIAL-INFARCTION IN DOGS - ALTERATIONS IN MAGNETIC-RELAXATION TIMES
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DOI：
10.1016/0002-9149(83)90093-0
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发表时间：
1983-01-01
影响因子：
2.8
通讯作者：
CROOKS, LE
中科院分区：
文献类型：
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作者：
HIGGINS, CB;HERFKENS, R;CROOKS, LE
使用 NMR 成像研究 8 只狗的 24 小时急性心肌梗塞。切除心脏的图像和测量结果是在 6.5 毫升内径电阻 NMR 成像仪（0.35 特斯拉）中获得的。在每种情况下，自旋回波核磁共振成像都表明，与正常心肌相比，梗塞区域是信号强度增加的区域。所有狗梗塞区域的 T1 和 T2 [磁弛豫时间] 值均大于正常心肌。对于每只狗来说，梗塞区域的 T1 值较大；然而，梗塞区域(728±.94)的T1(ms)组平均值并不显着大于正常区域(650±.87)。所有狗的 T2 值 (ms) 是有区别的，梗塞区域的平均值 (48.+-.2) 与正常心肌的值 (42.+-.1) 显着不同 (P < 0.01)。梗塞部位的含水量百分比（79±1%）显着高于正常区域（76±1%）（P<0.01）。 T2值与含水率之间的线性关系表现出良好的相关系数（r = 0.90；P < 0.01）。核磁共振成像无需造影剂即可以阳性图像检测急性心肌梗塞。梗塞信号强度的增加与氢密度的增加和T2弛豫时间的增加有关。
NMR imaging was used to study 24-h-old acute myocardial infarctions in 8 dogs. Images and measurements of excised hearts were obtained in a 6.5 ml bore-resistive NMR imager (0.35 Tesla). Spin echo NMR imaging in each instance demonstrated the area of infarction as a region of increased signal intensity compared with that in normal myocardium. The T1 and T2 [magnetic relaxation times] values of the area of infarction were greater than those of normal myocardium in all dogs. For each dog the T1 value was greater for the infarct region; however, the group mean value for T1 (ms) of the infarct region (728 .+-. 94) was not significantly greater than that for the normal region (650 .+-. 87). The T2 value (ms) was discriminate for all dogs, and the mean value for the infarct region (48 .+-. 2) was significantly different (P < 0.01) from the value for normal myocardium (42 .+-. 1). The percent water content of the infarct (79 .+-. 1%) was significantly greater (P < 0.01) than that of normal regions (76 .+-. 1%). The linear relationship between T2 value and percent water content showed a good correlation coefficient (r = 0.90; P < 0.01). NMR imaging detects acute myocardial infarction as a positive image without contrast media. Increased signal intensity of the infarct is related to increased hydrogen density and increased T2 relaxation time.