Antigen presentation of mucosal pathogens: the players and the rules.
Antigen presentation of mucosal pathogens: the players and the rules.
复制标题
粘膜病原体的抗原呈递：参与者和规则。
DOI：
10.1159/000237440
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发表时间：
1997
影响因子：
2.8
通讯作者：
Garofalo,R
中科院分区：
文献类型：
--
作者：
Reyes,VE;Ye,G;Ogra,PL;Garofalo,R
大量的传染性病原体通过粘膜表面进入宿主，而粘膜表面的总表面积比皮肤大得多。由于粘膜持续暴露于这些病原体，因此发展有效的局部免疫反应是至关重要的。在大多数免疫反应的发展过程中，一个必不可少的步骤是抗原由专门的辅助细胞（称为抗原呈递细胞（APC））呈递到T淋巴细胞。T细胞对抗原的识别很大程度上取决于APC如何处理抗原。复杂的抗原处理过程产生一组选定的肽，这些肽最终与MHC分子相关。结合肽的MHC分子的类型反过来决定了T淋巴细胞亚群识别肽的类型。因此，了解T细胞识别事件之前的分子和细胞过程是理解粘膜免疫反应如何发展的先决条件，也是研究疫苗开发的替代方法和控制自身免疫性疾病的治疗策略的先决条件。本文综述了抗原加工的细胞生物学以及不同APC群体如何参与粘膜反应。
A vast number of infectious pathogens gain entry into the host through mucosal surfaces, which have a much greater total surface area than the skin. Since the mucosa is continuously exposed to those pathogens, the development of an effective local immune response is of utmost importance. An obligatory step in the development of most immune responses is the presentation of antigens by specialized accessory cells, termed antigen-presenting cells (APC), to T lymphocytes. The recognition of antigens by T cells is largely determined by how the antigens are handled by the APC. Complex antigen-processing events generate a selected set of peptides which ultimately become associated with MHC molecules. The type of MHC molecules that bind the peptides in turn determine what T lymphocyte subset recognizes the peptides. Thus, an understanding of the molecular and cellular processes preceding the T cell recognition event is a prerequisite for understanding how mucosal immune responses develop, as well as for investigating alternative approaches to vaccine development and therapeutic strategies to control autoimmune diseases. This review discusses the cell biology of antigen processing and how various APC populations may participate in mucosal responses.