Target drug delivery technology (Carrying, releasing, penetrating) using acoustic bubbles embedded in an electromagnetically driven microrobot
Target drug delivery technology (Carrying, releasing, penetrating) using acoustic bubbles embedded in an electromagnetically driven microrobot
复制标题
使用嵌入电磁驱动微型机器人中的声泡的靶向药物输送技术（携带、释放、穿透）
DOI：
10.1109/memsys.2018.8346481
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
S. Chung
中科院分区：
文献类型：
--
作者：
Jinwon Jeong;Deasung Jang;S. Chung
本文提出了一种新型的靶向药物递送技术，即在电磁驱动微型机器人中嵌入不同体积的串联声泡。为了实现在任意形状的血管中游动的微型机器人的电磁驱动，制作了一种由一对亥姆霍兹和麦克斯韦线圈组成的电磁系统。利用所开发的电磁系统，成功地演示了由圆柱形钕磁铁制成的微型机器人在t形通道中的驱动。此外，在纯扩散、声波渗透和微流三种不同条件下，研究了声泡诱导的微流对药物组织渗透的影响。最后，作为概念验证，使用所提出的微型机器人和电磁系统在c形通道中成功演示了所提出的靶向药物递送技术。
This paper presents a novel target drug delivery technology using tandem acoustic bubbles with different volumes embedded in an electromagnetically driven microrobot. For the electromagnetic actuation of a microrobot swimming in arbitrarily shaped blood vessels, an electromagnetic system consisting of a pair of Helmholtz and Maxwell electric coils is fabricated. Using the developed electromagnetic system, the actuation of the microrobot made of a cylindrical neodymium magnet is successfully demonstrated in a T-shaped channel. In addition, the effects of microstreaming induced by acoustic bubbles on drug permeation to tissues are investigated for three different conditions — pure diffusion, permeation with an acoustic wave or microstreaming. Finally, as a proof of concept, the proposed target drug delivery technology is successfully demonstrated using the proposed microrobot and electromagnetic system in a C-shaped channel.