The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium.

The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium.
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DOI:
10.1186/bcr1411
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发表时间:
2006
期刊:
Breast cancer research : BCR
影响因子:
--
通讯作者:
Ormandy CJ
Ormandy CJ
中科院分区:
其他
文献类型:
--
作者:
Oakes SR;Hilton HN;Ormandy CJ

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怀孕期间乳腺内发生大量组织重塑,导致形成能够分泌乳汁的小叶泡。主要由催乳素和黄体酮产生的内分泌信号操作肺泡开关来启动这些发育事件。在这里,我们回顾了目前对肺泡开关组成部分的理解,并以检查 ets 转录因子 Elf5 的作用作为结论。我们认为 Elf5 是肺泡开关的关键调节因子。
Massive tissue remodelling occurs within the mammary gland during pregnancy, resulting in the formation of lobuloalveoli that are capable of milk secretion. Endocrine signals generated predominantly by prolactin and progesterone operate the alveolar switch to initiate these developmental events. Here we review the current understanding of the components of the alveolar switch and conclude with an examination of the role of the ets transcription factor Elf5. We propose that Elf5 is a key regulator of the alveolar switch.
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