Chronic low-level arsenic exposure reduces lung function in male population without skin lesions
Chronic low-level arsenic exposure reduces lung function in male population without skin lesions
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DOI：
10.1007/s00038-014-0567-5
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发表时间：
2014-08-01
影响因子：
4.6
通讯作者：
Ray, Manas Ranjan
中科院分区：
文献类型：
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作者：
Das, Debangshu;Bindhani, Banani;Ray, Manas Ranjan
在西孟加拉邦，调查了慢性低水平地下水砷暴露对呼吸的影响。将受试者(834名不吸烟成年男性)分为两组：砷暴露组446人，平均年龄35.3岁；对照组388人，饮用含砷10mg/L的地下水。采用原子吸收光谱法测定水样中的砷。呼吸道症状的患病率通过结构化、有效的问卷进行记录。采用便携式肺活量测定仪进行肺功能测定，与对照组相比，砷接触组的上下呼吸道症状、呼吸困难、哮喘、眼刺激和头痛的患病率较高。此外，20.6%的砷暴露者有肺功能障碍(以限制性和混合型为主)，而对照组为13.6%(p<；0.05)。饮用水中砷浓度与呼吸道症状的发生率呈正相关，而与肺活量参数呈负相关，提示即使是低水平的砷暴露也会对呼吸产生有害的影响。
The respiratory effects of chronic low-level arsenic exposure from groundwater have been investigated in West Bengal, India.The participants (834 non-smoking adult males) were subdivided in two groups: an arsenic-exposed group (n = 446, mean age 35.3 years) drinking arsenic-contaminated groundwater (11-50 mu g/L) and a control group of 388 age-matched men drinking water containing < 10 mu g/L of arsenic. Arsenic in water samples was measured by atomic absorption spectroscopy. The prevalence of respiratory symptoms was documented by structured, validated questionnaire. Pulmonary function test (PFT) was assessed by portable spirometer.Compared with control, the arsenic-exposed subjects had higher prevalence of upper and lower respiratory symptoms, dyspnea, asthma, eye irritation and headache. Besides, 20.6 % of arsenic-exposed subjects had lung function deficits (predominantly restrictive and combined types) compared with 13.6 % of control (p < 0.05). A positive association was observed between arsenic concentration in drinking water and the prevalence of respiratory symptoms, while a negative association existed between arsenic level and spirometric parameters.The findings suggest that even low-level arsenic exposure has deleterious respiratory effects.