The role of granzyme B cluster proteases in cell-mediated cytotoxicity.
The role of granzyme B cluster proteases in cell-mediated cytotoxicity.
复制标题
颗粒酶 B 簇蛋白酶在细胞介导的细胞毒性中的作用。
DOI：
10.1006/smim.1997.0060
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Ley,TJ
中科院分区：
文献类型：
--
作者：
Pham,CT;Ley,TJ
颗粒酶是中性丝氨酸蛋白酶，储存在细胞毒性淋巴细胞的特化裂解颗粒中。引入颗粒酶B位点的突变导致细胞毒性淋巴细胞诱导易感靶细胞凋亡的能力严重缺陷，并降低I类依赖性急性移植物抗宿主病（GvHD）的严重程度。然而，也存在颗粒酶B非依赖性细胞毒性：在CD8+细胞中，大部分是穿孔素依赖性的，但在CD4+细胞中，涉及Fas系统和另外的途径。这些途径的鉴定及其生理相关性可能导致抑制细胞毒性淋巴细胞功能的新方法。
Granzymes are neutral serine proteases that are stored in the specialized lytic granules of cytotoxic lymphocytes. A mutation introduced into the granzyme B locus leads to a severe defect in the ability of cytotoxic lymphocytes to induce apoptosis in susceptible target cells, and reduces the severity of class I-dependent acute graft-versus-host disease (GvHD). However, granzyme B-independent cytotoxicity also exists: in CD8+cells, most of it is perforin-dependent, but in CD4+cells, the Fas system and an additional pathway are involved. The identification of these pathways and their physiological relevance may lead to new approaches for inhibiting cytotoxic lymphocyte functions.