Relationship between the -374T/A RAGE gene polymorphism and angiographic coronary artery disease.
Relationship between the -374T/A RAGE gene polymorphism and angiographic coronary artery disease.
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-374T/A RAGE基因多态性与血管造影冠状动脉疾病的关系。
DOI：
10.3892/ijmm.14.6.1061
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发表时间：
2004
影响因子：
5.4
通讯作者：
M. Cuccia
中科院分区：
文献类型：
--
作者：
C. Falcone;I. Campo;E. Emanuele;M. P. Buzzi;M. Zorzetto;I. Sbarsi;M. Cuccia
晚期糖基化终产物受体（RAGE）被认为在糖尿病动脉粥样硬化中起关键作用。因此，RAGE基因启动子的功能性-374T/ a多态性与1型糖尿病患者的大血管并发症有关。然而，这种常见变异对普通人群冠状动脉疾病（CAD）风险的影响程度仍有待确定。我们对259名非糖尿病患者进行了-374T/A RAGE多态性基因分型，其中175人有冠状动脉造影记录（CAD患者），84人冠状动脉造影正常（无CAD对照组）。-374A等位基因的纯合性在9.7%的CAD患者和22.6%的非CAD患者中发现（p=0.005）。通过多元logistic回归分析，-374T/ a多态性的AA基因型与冠心病风险降低独立相关（校正优势比0.33,95% CI 0.15 ~ 0.73; p=0.006）。我们的观察结果表明，RAGE基因的-374T/A多态性可能降低对CAD的易感性，从而对冠状动脉风险起保护作用。未来的病理生理学研究可能有助于阐明这种关联背后的机制。
The receptor for advanced glycation end products (RAGE) is thought to play a critical role in diabetic atherosclerosis. Accordingly, a functional -374T/A polymorphism in RAGE gene promoter has been associated with macrovascular complications in type 1 diabetic patients. However, the extent to which this common variant influences the risk of coronary artery disease (CAD) in the general population remains to be determined. We genotyped the -374T/A RAGE polymorphism in 259 non-diabetic individuals, of whom 175 had angiographically documented coronary artery disease (CAD patients) and 84 had normal coronary angiography (CAD-free control subjects). Homozygosity for the -374A allele was found in 9.7% of the CAD patients versus 22.6% of the CAD-free subjects (p=0.005). By means of a multiple logistic regression analysis, the AA genotype of the -374T/A polymorphism was shown to be independently associated with a reduced risk of CAD (adjusted odds ratio 0.33, 95% CI 0.15 to 0.73; p=0.006). Our observations suggest that the -374T/A polymorphism of the RAGE gene may reduce susceptibility to CAD, thus exerting a protective effect on coronary risk. Future pathophysiological studies may be worthwhile to clarify the mechanisms behind this association.