Can we identify patients with low grade lymphoma for frontline ABMT?
Can we identify patients with low grade lymphoma for frontline ABMT?
复制标题
我们能否识别低度淋巴瘤患者进行一线 ABMT？
DOI：
10.3109/10428199309149105
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发表时间：
1993
影响因子：
2.6
通讯作者：
J. Romaguera
中科院分区：
文献类型：
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作者：
J. Romaguera
目前，自体骨髓移植（ABMT）是一种实验性手术，专为无法通过常规化疗治愈的患者保留。不幸的是，安娜堡分期系统无法识别这些病例，因为有些 IV 期患者表现良好，而另一些则表现不佳。我们报告了一种基于性别和肿瘤负荷 (TB) 评估的风险模型，该模型可以将安娜堡 IV 期滤泡性低度恶性淋巴瘤 (FLGL) 患者分为三个预后组：(a) 一组低度 TB 女性，她们已达到无失败生存 (FFS) 平台，生存率分别为 50% 和 92%，且不应接受一线 ABMT； (b) 一群患有高结核病的男性，其中位 FFS 和生存期分别仅为 12 个月和 48 个月，并且可能从 ABMT 中受益； (c) 一大群患有其他性别组合的结核病患者，在十年的随访中不断复发，并且生存率很低。即使其中一些十年生存率至多为 50% 的人，其生存曲线也尚未达到稳定水平。与所有 IV 期患者一样，这一大群患者在初次诊断和治疗时的中位年龄为 60 岁，到复发时可能已超过 60 岁，此时挽救治疗将增加发病率和死亡率，如果包括 ABMT，则更是如此。（摘要截断为 250 字）
Autologous Bone Marrow Transplant (ABMT), at this point, is an experimental procedure reserved for patients without cure potential with available conventional chemotherapy. Unfortunately, the Ann Arbor staging system has not been able to identify these cases since there are patients with Stage IV who do well and others who do not. We have reported on a risk model based on gender and tumor burden (TB) assessment that can stratify patients with uniform Ann Arbor stage IV follicular low-grade lymphoma (FLGL) into three prognostic groups: (a) a group of females with low TB who have achieved a plateau of failure free survival (FFS) and survival of 50% and 92%, respectively, and who should not receive frontline ABMT; (b) a group of males with high TB having a median FFS and survival of only 12 and 48 months, respectively, and who could potentially benefit from ABMT; (c) a large group of patients with other TB-sex combinations, who are continuously relapsing at ten year follow-up, and whose survival is dismal. Even some of these, who have at best a 50% ten year survival, have not reached a plateau in their survival curves. This large group of patients, like all stage IV patients, will have a median age of 60 years at the time of initial diagnosis and treatment, and will be probably over 60 years old by the time they relapse, at which time salvage therapy will have increased morbidity and mortality, more so if it includes ABMT.(ABSTRACT TRUNCATED AT 250 WORDS)
对 69 名有低度 B 细胞非霍奇金淋巴瘤病史的患者进行自体骨髓移植。
影响因子：
20.3
作者：
Freedman,AS;Ritz,J;Neuberg,D;Anderson,KC;Rabinowe,SN;Mauch,P;Takvorian,T;Soiffer,R;Blake,K;Yeap,B
通讯作者：
Yeap,B
III 期滤泡性淋巴瘤：通过联合化疗-放疗方案实现持久缓解。
DOI：
10.1200/jco.1987.5.6.867
发表时间：
1987
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
McLaughlin,P;Fuller,LM;Velasquez,WS;Butler,JJ;Hagemeister,FB;Sullivan-Halley,JA;Dixon,DO
通讯作者：
Dixon,DO