Effects of HZE particle on the nigrostriatal dopaminergic system in a future mars mission
Effects of HZE particle on the nigrostriatal dopaminergic system in a future mars mission
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DOI：
10.1016/j.actaastro.2004.05.068
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发表时间：
2005-02-01
影响因子：
3.5
通讯作者：
Mohler, S
中科院分区：
文献类型：
--
作者：
Koike, Y;Frey, MA;Mohler, S
由于银河宇宙线中的富铁高能粒子在地球磁场之外的传播时间较长，对人体的影响是辐射防护的主要关注点。最近除了诱变作用之外，注意力还集中在对中枢神经系统的影响上。特别是，研究人员在地面哺乳动物研究中使用加速铁离子报告了黑质纹状体多巴胺能系统中纹状体多巴胺含量的减少。此外，帕金森病的病理生理学研究表明，过量的铁会导致黑质中的多巴胺含量减少。这提出了一种有趣的可能性来解释 HZE 颗粒对多巴胺能系统的选择性有害影响。如果这些颗粒具有生化作用，可能的对策选择是：（1）营养预防，（2）药物治疗，以及（3）通过手术将刺激器电极放置在基底神经节的特定解剖部位。 (C) 2004 Elsevier Ltd. 保留所有权利。
Because of long duration travel outside the Earth's magnetic field, the effect of iron-rich high charge and energy (HZE) particles in Galactic Cosmic Rays on human body is the major concern in radiation protection. Recently attention has been directed to effects on the central nervous system in addition to mutagenic effects. In particular, a reduction in striatal dopamine content on nigrostriatal dopaminergic system has been reported by investigators using accelerated iron ions in ground-based mammalian studies. In addition, studies of the pathophysiology of Parkinson's disease demonstrated that excess iron cause a reduction in the dopamine content in the substantia nigra. This suggests an intriguing possibility to explain the selective detrimental effects of HZE particles on the dopaminergic system. Should these particles have biochemical effects, possible options for countermeasures are: (1) nutritional prevention, (2) medication, and (3) surgical placement of a stimulator electrode at a specific anatomic site in the basal ganglia. (C) 2004 Elsevier Ltd. All rights reserved.