Blood vitamins, mineral elements and inflammation markers as risk factors of vascular and non-vascular disease mortality in an elderly population
Blood vitamins, mineral elements and inflammation markers as risk factors of vascular and non-vascular disease mortality in an elderly population
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DOI：
10.1093/ije/27.5.799
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发表时间：
1998-10-01
影响因子：
7.7
通讯作者：
Sourander, L
中科院分区：
文献类型：
--
作者：
Marniemi, J;Järvisalo, J;Sourander, L
背景已经提出老年人对保护剂抵抗身体退化过程的需求特别高。为了评估各种生化因素在老龄化的预后价值的协会的血液中的几种维生素，矿物质元素和其他一些建议的危险因素与血管和非血管mortars.Methods的血管性和非血管性的老年population.A大型健康调查进行了研究，完整的临床评价在城市的图尔库在1982-1983年。随机抽取344名65岁以上的社区老年人，分为四个年龄组进行了研究。在13年的随访中，225名受试者死亡。从血液标本中分析钙、镁、铜、血浆铜蓝蛋白、锌、硒、铁、铁蛋白、转铁蛋白、α-生育酚、视黄醇、叶酸、维生素B-12、丙二醛、类粘蛋白和胰岛素水平。在13年的随访期间测量的化合物和相对死亡率的风险之间的关系进行了分析调整其他已知的风险factors.Results和结论考克斯比例风险模型高浓度的血清铜，orosomucoid和胰岛素相关的结论与血管死亡的风险增加。在调整了许多混杂危险因素后，受试者血清浓度最高三分位数的相对风险分别为铜2.2、类粘蛋白1.8和胰岛素1.8。低血清维生素B12浓度似乎与血管死亡率增加显著相关（P = 0.01）。当仅根据年龄进行调整时，这种关联基本上并不显著。与早期的观察结果相反，当调整混杂危险因素时，血清镁、硒、α-生育酚、铁及其结合蛋白或血浆和红细胞叶酸浓度与死亡风险增加无关。作者认为，在老年受试者中，这些元素和化合物是最弱的，可能是血管死亡的非独立危险因素。
Background The need for protecting agents against degenerative processes of the body has been proposed to be especially high in elderly people. In order to evaluate the prognostic value of various biochemical factors in ageing the associations of blood concentrations of several vitamins, mineral elements and some other suggested risk factors with vascular and non-vascular mortality were studied in an elderly population.Methods A large health survey with complete clinical evaluation was carried out in the City of Turku in 1982-1983. A random sample of 344 community-living elderly individuals aged 65 years or older, stratified into four age groups, was studied. During the 13 years follow-up 225 subjects had died. Calcium, magnesium, copper, ceruloplasmin, zinc, selenium, iron, ferritin, transferrin, alpha-tocopherol, retinol, folate, vitamin B-12, malondialdehyde, orosomucoid and insulin levels were analysed from the blood specimens. The relations between the compounds measured and relative mortality risks during the 13-year follow-up were analysed by Cox proportional hazards model adjusting for other known risk factors.Results and Conclusions High concentrations of serum copper, orosomucoid and insulin were associated Conclusions with increased risk of vascular mortality. The relative risks within the subjects of the highest tertile of serum concentrations were 2.2 for copper, 1.8 for orosomucoid, and 1.8 for insulin when adjusted for many confounding risk factors. Low serum vitamin B12 concentrations appeared to be significantly (P = 0.01) associated with increased vascular mortality. The associations were essentially not more significant when adjusted only for age. Contrary to earlier observations, concentrations of serum magnesium, selenium, alpha-tocopherol, iron and its binding proteins or plasma and erythrocyte folate were not associated with increased mortality risk when adjusted for confounding risk factors. The authors suggest that in elderly subjects these elements and compounds are at the most weak, and probably non-independent risk factors for vascular mortality.