Dynamic sculpting of directional tuning in the primate motor cortex during three-dimensional reaching
Dynamic sculpting of directional tuning in the primate motor cortex during three-dimensional reaching
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DOI：
10.1523/jneurosci.1898-08.2008
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发表时间：
2008-09-10
影响因子：
5.3
通讯作者：
Georgopoulos, Apostolos P.
中科院分区：
文献类型：
--
作者：
Merchant, Hugo;Naselaris, Thomas;Georgopoulos, Apostolos P.
在本研究中，我们研究了如何从相邻的中间神经元抑制的方向调谐的假定锥体细胞锐化。首先，不同的功能和电生理标准被用来确定假定的锥体和interneuronal亚型在一个大型的数据库中的运动皮层细胞记录在性能的三维中心任务。然后，我们分析了抑制的幅度和调谐宽度之间的关系，和一个显着的减少，后者作为前者的函数被发现在一个人口的推定锥体细胞。事实上，耦合的抑制与窄调谐之前和期间观察到的运动执行细胞的基础上，表明一个重要的动态作用的抑制在运动控制。总体而言，这些结果表明，局部抑制参与了运动皮层中一组假定的锥体神经元的方向特异性的塑造。
In the present study, we investigated how directional tuning of putative pyramidal cells is sharpened by inhibition from neighboring interneurons. First, different functional and electrophysiological criteria were used to identify putative pyramidal and interneuronal subtypes in a large database of motor cortical cells recorded during performance of the three-dimensional center-out task. Then we analyzed the relationship between the magnitude of inhibition and the tuning width, and a significant decrease of the latter as a function of the former was found in a population of putative pyramidal cells. In fact, the coupling of inhibition with narrow tuning was observed before and during movement execution on a cell-by-cell basis, indicating an important dynamic role of inhibition during movement control. Overall, these results suggest that local inhibition is involved in sculpting the directional specificity of a group of putative pyramidal neurons in the motor cortex.