Soluble Human Leukocyte Antigen G Molecule Expression in Allogeneic Hematopoietic Stem Cell Transplantation: Good Predictor of Acute Graft-versus-Host Disease
Soluble Human Leukocyte Antigen G Molecule Expression in Allogeneic Hematopoietic Stem Cell Transplantation: Good Predictor of Acute Graft-versus-Host Disease
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DOI：
10.1159/000350488
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发表时间：
2013-01-01
影响因子：
2.4
通讯作者：
Liu, Qifa
中科院分区：
文献类型：
--
作者：
Liu, Hui;Chen, Yinkui;Liu, Qifa
背景：移植物抗宿主病（GVHD）是异基因造血干细胞移植（allo-HSCT）的主要并发症。人类白细胞抗原G（HLA-G）是一种具有多种免疫调节功能的非经典I类分子。本研究的目的是探讨可溶性HLA-G（sHLA-G）与allo-HSCT后GVHD的关系。研究方法：采用酶联免疫吸附试验（ELISA）检测106例恶性血液病患者移植前、移植后+15、+30 d及10例健康志愿者的sHLA-G水平。结果如下：移植后15、30天sHLA-G5、sHLA-G6、sHLA-G7水平均较移植前显著升高（均P < 0.05），移植后15、30天sHLA-G6、sHLA-G7水平均较移植前显著升高（均P < 0.05），移植后30天sHLA-G6、sHLA-G7水平均较移植前显著升高（均P < 0.05）。
Background: Graft-versus-host disease (GVHD) remains a main complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Human leukocyte antigen G (HLA-G) is a non-classical class I molecule exerting multiple immunoregulatory functions. The aim of this study was to explore the relationship between soluble HLA-G (sHLA-G) and GVHD after allo-HSCT. Methods: The sHLA-G levels were examined using enzyme-linked immunosorbent assay in patients with hematological malignancies (n = 106) before transplantation, on days +15 and +30 after transplantation, as well as healthy volunteers (n = 10). Results: The levels of sHLA-G5, sHLA-G6 and sHLA-G7 in patients on days +15 and +30 after transplantation were all significantly higher than those before transplantation (all p