Anesthesia in children--limitations of the data on neurotoxicity.
Anesthesia in children--limitations of the data on neurotoxicity.
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儿童麻醉——神经毒性数据的局限性。
DOI：
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发表时间：
2011
影响因子：
158.5
通讯作者：
S. Malviya
中科院分区：
文献类型：
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作者：
N. Glass;S. Malviya
致编辑：我们同意Rappaport等人在本期杂志上发表的关于麻醉剂与幼儿神经损伤之间可能关系的观点文章中表达的担忧。然而，临床医生面临的挑战是将动物模型的神经发育阶段和行为相关性外推到人类婴儿。动物研究揭示了麻醉后令人担忧的神经元凋亡，这引发了儿科麻醉师是否应该改变他们的做法以及他们应该告诉父母什么的问题。动物研究涉及长时间暴露于高剂量麻醉剂，并进行可变监测，且无手术应激。此外，翻译大脑发育的各个阶段......
To the Editor: We share the concerns that Rappaport et al. express in their Perspective article in this issue of the Journal regarding possible relationships between anesthetic agents and neurologic damage in young children. However, clinicians are challenged with extrapolating neurodevelopmental stages and behavioral correlates from animal models to human infants. Studies in animals reveal worrisome neuronal apoptosis after anesthesia, raising questions about whether pediatric anesthesiologists should change their practice and what they should tell parents. Studies in animals involve prolonged exposure to anesthetics in high doses with variable monitoring and no surgical stress. Furthermore, translating stages of brain development . . .
影响因子：
9.8
作者：
Sun, L.
通讯作者：
Sun, L.