In vitro evaluation of the efficacy of a silver-coated catheter
In vitro evaluation of the efficacy of a silver-coated catheter
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DOI：
10.1007/s002849900064
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发表时间：
1996-07-01
影响因子：
2.6
通讯作者：
Ahearn, DG
中科院分区：
文献类型：
--
作者：
Gabriel, MM;Mayo, MS;Ahearn, DG
在体外检查了通常与医院尿路感染相关的细菌对乳胶、100%硅胶、水凝胶涂层乳胶和水凝胶/银涂层乳胶导尿管的相对粘附性。用亮氨酸放射性标记的细胞测定2小时内的粘附程度。硅胶和乳胶导管的粘附性最大且相当。与其他导管相比，四种大肠杆菌菌株对水凝胶/银涂层导管的粘附性降低了50%至99%。用E.大肠杆菌和铜绿假单胞菌与超过50个导管的抑制表现出一致性。导管的亲水涂层似乎是粘附现象减少的主要原因，其次是银离子的次要杀生物作用。
Bacteria commonly associated with nosocomial urinary tract infections were examined in vitro for their relative adherence to latex, 100% silicone-, hydrogel-coated latex-, and hydrogel/silver-coated latex urinary catheters. Degrees of adherence within 2 h were determined with cells radiolabeled with leucine. Adherence was greatest and equivalent on silicone and latex catheters. Adherence of four strains of Escherichia coli to the hydrogel/silver-coated catheter was decreased by 50% to 99% in comparison with the other catheters. Repeat testing with strains of E. coli and Pseudomonas aeruginosa with over 50 catheters demonstrated a consistency in the inhibition. The hydrophilic coating of the catheter appeared to be primary in the decreased adherence phenomenon followed by a secondary biocidal effect of the silver ion.