The neuronal response to electrical constant-amplitude pulse train stimulation: evoked compound action potential recordings
The neuronal response to electrical constant-amplitude pulse train stimulation: evoked compound action potential recordings
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DOI：
10.1016/s0378-5955(00)00172-6
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发表时间：
2000-11-01
期刊：
影响因子：
2.8
通讯作者：
Miller, CA
中科院分区：
文献类型：
--
作者：
Matsuoka, AJ;Abbas, PJ;Miller, CA
本研究的目的是获得一个更好的了解电诱发复合动作电位（EAP）脉冲串刺激的反应。EAP振幅反应的分析表明，交替模式不同，这取决于刺激水平，脉冲间隔（IPI），刺激波形，刺激极性。在猫和豚鼠中观察到刺激水平依赖性恢复。较高的刺激水平往往提供更快的恢复。在猫中观察到极性依赖性恢复和极性依赖性适应，并且这些刺激极性效应在豚鼠中不太一致。极性依赖性恢复效应支持了阳极和阴极刺激沿沿着听觉神经纤维激发不同部位的假设。在所有猫中，对第二脉冲的反应和在相同IPI下的稳态反应之间的振幅差异对于阳极刺激比阴极刺激显著更大。这些数据表明，有一个累积的不应效应在猫的听神经，特别是在响应阳极刺激。(C)2000 Elsevier Science B.V.保留所有权利。
The purpose of this study was to gain a greater understanding of the electrically evoked compound action potential (EAP) responses to pulse train stimulation. Analysis of EAP amplitude responses suggested that an alternating pattern varied depending upon stimulus level, interpulse interval (IPI), stimulus waveform, and stimulus polarity. Stimulus level-dependent recovery was seen in the cat and the guinea pig. higher stimulus level tended to provide faster recovery. Both polarity-dependent recovery and polarity-dependent adaptation were observed in the cat and these stimulus polarity effects were less consistent in the guinea pig. The polarity-dependent recovery effect supports the hypothesis that anodal and cathodal stimuli excite different sites along auditory nerve fibers. Amplitude differences between the response to the second pulse and the steady-state response at the same IPI are significantly greater for anodal stimuli than for cathodal stimuli in all cats. These data suggest that there is a cumulative refractory effect in the auditory nerve of cats, especially in response to anodal stimuli. (C) 2000 Elsevier Science B.V. All rights reserved.