BOVINE AORTIC ENDOTHELIAL-CELLS DISPLAY MACROPHAGE-LIKE PROPERTIES TOWARDS ACETYLATED I-125-LABELED LOW-DENSITY LIPOPROTEIN
BOVINE AORTIC ENDOTHELIAL-CELLS DISPLAY MACROPHAGE-LIKE PROPERTIES TOWARDS ACETYLATED I-125-LABELED LOW-DENSITY LIPOPROTEIN
复制标题
DOI：
10.1016/0005-2760(80)90155-1
复制
发表时间：
1980-01-01
期刊：
影响因子：
--
通讯作者：
STEIN, Y
中科院分区：
文献类型：
--
作者：
STEIN, O;STEIN, Y
培养的牛主动脉内皮细胞优先摄取和降解乙酰化125 I标记的低密度脂蛋白（125 I-乙酰化LDL），而不是125 I标记的低密度脂蛋白（LDL）。汇合培养的内皮细胞比亚汇合细胞具有更高的125 I-乙酰化LDL降解率。125 I-acetylated LDL与125 I-LDL的降解比在内皮细胞中为3-9，在主动脉平滑肌细胞中为0.06-0.11，在小鼠腹腔巨噬细胞中为18。内皮细胞对乙酰化LDL的摄取和降解伴随着细胞胆固醇的增加。培养的内皮细胞对血清脂蛋白明显显示出某些巨噬细胞样特性。
Bovine aortic endothelial cells in culture take up and degrade acetylated 125I-labeled low density lipoproteins (125I-acetylated LDL) in preference to 125I-labeled low density lipoproteins (LDL). The confluent cultures of endothelial cells had a higher rate of degradation of 125I-acetylated LDL than did subconfluent cells. The ratio of degradation of 125I-acetylated LDL to 125I-LDL was 3-9 in the case of the endothelial cells, 0.06-0.11 for aortic smooth muscle cells and 18 for mouse peritoneal macrophages. The uptake and degradation of acetylated LDL by the endothelial cells was accompanied by an increase in cellular cholesterol. Cultured endothelial cells evidently display certain macrophage-like properties towards serum lipoproteins.