Novel deprotection method of Fmoc group under neutral hydrogenation conditions
Novel deprotection method of Fmoc group under neutral hydrogenation conditions
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DOI：
10.1007/s00726-008-0109-7
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发表时间：
2009-03-01
期刊：
影响因子：
3.5
通讯作者：
Sajiki, Hironao
中科院分区：
文献类型：
--
作者：
Maegawa, Tomohiro;Fujiwara, Yuta;Sajiki, Hironao
开发了在室温下 Pd/C 催化氢化条件下 Fmoc（9-芴基甲氧基羰基）保护基脱保护的新方法。 CH3CN的添加加速了Fmoc基团的脱保护，并且H-2压力(3atm)的应用也显示出显着的速率提高。
Novel deprotection method of the Fmoc (9-flurorenylmethoxycarbonyl) protective group under Pd/C-catalyzed hydrogenation conditions at room temperature was developed. The addition of CH3CN accelerated the deprotection of the Fmoc group, and also the application of H-2 pressure (3 atm) shows notable rate enhancement.