Motor impairments at presentation of clinically isolated syndrome suggestive of multiple sclerosis: Characterization of different disease subtypes
Motor impairments at presentation of clinically isolated syndrome suggestive of multiple sclerosis: Characterization of different disease subtypes
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DOI：
10.3233/nre-2012-0784
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发表时间：
2012-01-01
影响因子：
2
通讯作者：
Dvir, Zeevi
中科院分区：
文献类型：
--
作者：
Kalron, Alon;Achiron, Anat;Dvir, Zeevi
目的：为了评估最近诊断的临床孤立综合征（CIS）提示MS患者的运动障碍的频率。方法：神经系统检查后，CIS患者被分为两组，根据发病时涉及的功能系统的数量。各组包括单症状（n = 35，平均EDSS = 1.3 +/- 0.2）和多症状（n = 17，平均EDSS = 2.6 +/- 0.1）患者。运动评估包括在双侧膝关节和踝关节测量的等长扭矩峰值和疲劳指数（FI）以及步态和姿势控制的时空参数。使用MSAnalyze计算机化软件在3.0T脑MRI上测量损伤负荷和萎缩。28名年龄和性别匹配的健康受试者作为对照组的运动assessment.Results：多症状患者表现出降低的峰值强度和FI，较慢的步态速度，狭窄的基础上的支持和增加摇摆率相比，健康受试者和单症状患者。此外，多症状和单一症状患者的T2加权体积病变（mm（3））的中位数评分分别为4875和1628.Conclusions：证据表明，两个亚型的CIS建立在上下文与MRI结果和运动缺陷。区分这些组可以潜在地改善MS患者在疾病过程的初始阶段的管理。
Objectives: To evaluate the frequency of motor impairments in patients with recently diagnosed clinically isolated syndrome (CIS) suggestive of MS.Methods: Following a neurological examination, patients with CIS were subdivided into two groups according to the number of functional systems involved at onset. Groups consisted of monosymptomatic (n = 35, mean EDSS = 1.3 +/- 0.2) and polysymptomatic (n = 17, mean EDSS = 2.6 +/- 0.1) patients. Motor assessment included peak isometric torque and fatigue index (FI) measured at the knee and ankle bilaterally and spatiotemporal parameters of gait and postural control. Lesion load and atrophy were measured on a 3.0T brain MRI using MSAnalyze computerized software. Twenty eight age-and gender-matched healthy subjects served as controls for motor assessment.Results: Polysymptomatic patients demonstrated reduced peak strength and FI, slower gait velocity, narrower base of support and increased sway rate compared to healthy subjects and mono-symptomatic patients. Furthermore, polysymptomatic and monosymptomatic patient median score in T2-weighted volume lesions (mm(3)) was 4875 and 1628, respectively.Conclusions: Evidence of two subtypes of CIS was established in context with MRI findings and motor deficits. Differentiating between these groups can potentially improve management of MS patients at the initial stages of the disease process.