Evaluation of Potential Donors in Living Donor Liver Transplantation
Evaluation of Potential Donors in Living Donor Liver Transplantation
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DOI：
10.1016/j.transproceed.2015.04.045
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发表时间：
2015-06-01
影响因子：
0.9
通讯作者：
Yilmaz, S.
中科院分区：
文献类型：
--
作者：
Dirican, A.;Baskiran, A.;Yilmaz, S.
介绍。在活体肝移植（LDLT）中，正确的供体选择不仅对降低供体并发症的风险，而且对提高移植物和受体的存活率至关重要。了解最常见的供体被淘汰的原因对移植中心争取时间非常重要。在这项研究中，我们评估了潜在供体在LDLT中的有效性，并研究了我们移植中心潜在肝供体不成熟的原因。患者和方法。我们研究了2013年1月至2014年6月期间，342名潜在活体供体候选人和161名肝移植受体候选人的结果。记录候选供体的性别、年龄、身体质量指数（BMI）、与受体的关系以及排除原因。在161名受者中，96名接受了LDLT， 7名接受了尸体肝移植。342个潜在捐助者中有12个没有完成评估；在剩余的330例候选供体中，106例（32%）被接受为适合捐赠，但其中10例被术前排除。不适宜捐献肝脏的主要原因是残肝体积小（43%）和肝脏脂肪改变（38.4%）。其他原因包括动脉解剖变异、ABO血型不合和吉尔伯特综合征。在完成评估的330名候选人中，只有96名（29%）接受了捐赠。有效供者占潜在供者的29%，适宜供者的90.5%。本中心330例候选供者中有106例（32%）适合捐献，不适合捐献肝的主要原因是残肝体积小、肝脏脂肪改变。
Introduction. Correct donor selection in living donor liver transplantation (LDLT) is essential not only to decrease the risks of complications for the donors but also to increase the survival of both the graft and the recipient. Knowing their most frequent reasons of donor elimination is so important for transplantation centers to gain time. In this study we evaluated the effectiveness of potential donors in LDLT and studied the reasons for nonmaturation of potential liver donors at our transplantation center.Patients and Methods. We studied the outcomes of 342 potential living donor candidates for 161 recipient candidates for liver transplantation between January 2013 and June 2014. Donor candidates' gender, age, body mass index (BMI), relationship with recipient, and causes of exclusion were recorded.Results. Among 161 recipients, 96 had a LDLT and 7 had cadaveric liver transplantation. Twelve of the 342 potential donors did not complete their evaluation; 106 of the remaining 330 donor candidates were accepted as suitable for donation (32%) but 10 of these were excluded preoperatively. The main reasons for unsuitability for liver donation were small remnant liver size (43%) and fatty changes of the liver (38.4%). Other reasons were arterial anatomic variations, ABO incompatibility, and Gilbert syndrome. Only 96 of the candidates (29% of the 330 candidates who completed the evaluation) underwent donation. Effective donors were 29% of potential and 90.5% of suitable donors.Conclusions. In our center, 106 of 330 (32%) donor candidates were suitable for donation and the main reasons for unsuitability for liver donation were small remnant liver size and fatty changes of the liver.