Spanish Mediterranean diet and other dietary patterns and breast cancer risk: case-control EpiGEICAM study.
Spanish Mediterranean diet and other dietary patterns and breast cancer risk: case-control EpiGEICAM study.
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DOI：
10.1038/bjc.2014.434
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发表时间：
2014-09-23
影响因子：
8.8
通讯作者：
Martin, M.
中科院分区：
文献类型：
--
作者：
Castello, A.;Pollan, M.;Buijsse, B.;Ruiz, A.;Casas, A. M.;Baena-Canada, J. M.;Lope, V.;Antolin, S.;Ramos, M.;Munoz, M.;Lluch, A.;de Juan-Ferre, A.;Jara, C.;Jimeno, M. A.;Rosado, P.;Diaz, E.;Guillem, V.;Carrasco, E.;Perez-Gomez, B.;Vioque, J.;Boeing, H.;Martin, M.
虽然关于饮酒的有害影响有确凿的发现，但其他饮食因素对乳腺癌（BC）风险影响的现有证据尚不确定。本研究旨在评估西班牙女性的饮食模式与BC风险之间的相关性，按绝经状态和肿瘤亚型进行分层，并将结果与替代健康指数（AHEI）和替代地中海饮食评分（aMED）进行比较。我们招募了1017例偶发性BC病例和1017例年龄相似（±5岁）且无BC病史的匹配健康对照。使用logistic和多项式回归模型评估了“先验”和“后验”饮食模式与BC之间的关联，以及根据绝经状态和内在肿瘤亚型（ER+/PR+和HER 2 − HER 2+以及ER−/PR−和HER 2 −）。坚持西方饮食模式与较高的BC风险相关（OR为顶部与底部四分位数1.46（95% CI 1.06-2.01）），特别是在绝经前妇女（OR=1.75; 95% CI 1.14-2.67）。相比之下，地中海模式与较低的风险相关（上四分位数与下四分位数的OR为0.56（95% CI 0.40-0.79））。尽管在所有肿瘤亚型中均观察到Western模式的有害作用，但我们的地中海模式对三阴性肿瘤的保护作用更强（OR=0.32; 95%CI 0.15-0.66和P异质性=0.04）。没有发现遵守谨慎模式和BC风险之间的关联。“先验”指数与BC风险之间的关联不太明显（AHEI的上四分位数与下四分位数的OR =0.69; 95%CI 0.51-0.94和aMED=0.74; 95%CI 0.46-1.18）。我们的研究结果证实了西方饮食对BC风险的有害影响，并增加了新的证据，证明富含水果，蔬菜，豆类，油性鱼类和植物油的饮食对预防所有BC亚型，特别是三阴性肿瘤的益处。
Although there are solid findings regarding the detrimental effect of alcohol consumption, the existing evidence on the effect of other dietary factors on breast cancer (BC) risk is inconclusive. This study aimed to evaluate the association between dietary patterns and risk of BC in Spanish women, stratifying by menopausal status and tumour subtype, and to compare the results with those of Alternate Healthy Index (AHEI) and Alternate Mediterranean Diet Score (aMED). We recruited 1017 incident BC cases and 1017 matched healthy controls of similar age (±5 years) without a history of BC. The association between ‘a priori' and ‘a posteriori' developed dietary patterns and BC in general and according to menopausal status and intrinsic tumour subtypes (ER+/PR+ and HER2− HER2+ and ER−/PR− and HER2−) was evaluated using logistic and multinomial regression models. Adherence to the Western dietary pattern was related to higher risk of BC (OR for the top vs the bottom quartile 1.46 (95% CI 1.06–2.01)), especially in premenopausal women (OR=1.75; 95% CI 1.14–2.67). In contrast, the Mediterranean pattern was related to a lower risk (OR for the top quartile vs the bottom quartile 0.56 (95% CI 0.40–0.79)). Although the deleterious effect of the Western pattern was similarly observed in all tumour subtypes, the protective effect of our Mediterranean pattern was stronger for triple-negative tumours (OR=0.32; 95% CI 0.15–0.66 and Pheterogeneity=0.04). No association was found between adherence to the Prudent pattern and BC risk. The associations between ‘a priori' indices and BC risk were less marked (OR for the top vs the bottom quartile of AHEI=0.69; 95% CI 0.51–0.94 and aMED=0.74; 95% CI 0.46–1.18)). Our results confirm the harmful effect of a Western diet on BC risk, and add new evidence on the benefits of a diet rich in fruits, vegetables, legumes, oily fish and vegetable oils for preventing all BC subtypes, and particularly triple-negative tumours.
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影响因子：
1.9
作者：
Grosso, Giuseppe;Buscemi, Silvio;Biondi, Antonio
通讯作者：
Biondi, Antonio
影响因子：
6.4
作者：
Buckland, G.;Travier, N.;Riboli, E.
通讯作者：
Riboli, E.
影响因子：
12.4
作者：
Paul, A.;Gunewardena, S.;Paul, S.
通讯作者：
Paul, S.
影响因子：
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作者：
Barkoukis, Hope
通讯作者：
Barkoukis, Hope
影响因子：
45.3
作者：
Hammond, M. Elizabeth H.;Hayes, Daniel F.;Wolff, Antonio C.
通讯作者：
Wolff, Antonio C.