Evolution of cervical cytologic changes among HIV-infected women with normal cytology in the HAART era.
Evolution of cervical cytologic changes among HIV-infected women with normal cytology in the HAART era.
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HAART时代细胞学正常的HIV感染女性宫颈细胞学变化的演变。
DOI：
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发表时间：
2007
影响因子：
1.5
通讯作者：
B. Clotet
中科院分区：
文献类型：
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作者：
G. Sirera;S. Videla;R. Lopez;M. Llatjós;A. Tarrats;E. Castellà;N. Grane;C. Alcalde;C. Tural;C. Rey‐Joly;B. Clotet
研究了HAART对HAART时代细胞学检查正常的HIV（+）妇女宫颈鳞状上皮内病变（SIL）演变的影响。对接受HAART治疗的HIV感染妇女进行了回顾性队列研究（1997-2005年）。包括那些正常的宫颈细胞学（巴氏试验）和至少一个后续测试。生存期（直到诊断为SIL的时间），单变量和多变量分析。共纳入133例接受HAART治疗的HIV感染患者。SIL发生率为35%（47例患者）。在基线和最终免疫状态>200 CD 4细胞/μ l的110例患者中有36例（33%）被诊断为SIL，在基线和最终免疫状态≤ 200 CD 4的9例患者中有6例（67%）被诊断为SIL（OR：0.24，95% CI：0.06-1.03，p = 0.041）。在基线和最终HIV病毒载量检测不到的60例患者中有10例（17%）被诊断为SIL，在可检测到HIV病毒载量的70例患者中有36例（51%）被诊断为SIL（OR：0.19，95%CI：0.07-0.46，p < 0.001）。在没有宫颈病理学背景的HIV（+）妇女中观察到SIL（癌前病变）的高发病率。HAART对控制HIV复制和免疫状态（>200 CD 4）的影响与SIL的减少有关。
The influence of HAART on the evolution to cervical squamous intraepithelial lesions (SIL) among HIV(+) women with a normal cytological test in the HAART era was studied. A retrospective cohort study (1997-2005) of HIV-infected women treated with HAART was conducted. Those with a normal cervical cytology (Papanicolaou test) and at least one subsequent test were included. Survival (time until diagnosis of SIL), univariate, and multivariate analyses were performed. A total of 133 HIV-infected patients treated with HAART were included. The incidence of SIL was 35% (47 patients). SIL was diagnosed in 36 of 110 (33%) patients with a baseline and final immunological status of >200 CD4 cells/microl and in 6 of 9 (67%) patients with a baseline and final immunological status of < or =200 CD4 (OR: 0.24, 95% CI: 0.06-1.03, p = 0.041). SIL was diagnosed in 10 of 60 (17%) patients with an undetectable baseline and final HIV viral load and in 36 of 70 (51%) patients with a detectable HIV viral load (OR: 0.19, 95% CI: 0.07-0.46, p < 0.001). A high incidence of SIL (cancer precursor lesions) was observed among HIV(+) women without a background of cervical pathology. The effect of HAART on the control of HIV replication and of immunological status (>200 CD4) through the follow-up was associated with a reduction of SIL.
影响因子：
120.7
作者：
Stoler, MH;Schiffman, M
通讯作者：
Schiffman, M
影响因子：
10.3
作者：
HO, GYF;BURK, RD;ROMNEY, S
通讯作者：
ROMNEY, S
DOI：
10.1093/jnci/93.4.293
发表时间：
2001-02-21
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
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作者：
Solomon, D;Schiffman, M;Tarone, R
通讯作者：
Tarone, R