Effects of partial portal vein arterialization on liver regeneration after hepatectomy in minipigs with obstructive jaundice
Effects of partial portal vein arterialization on liver regeneration after hepatectomy in minipigs with obstructive jaundice
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DOI：
10.3760/cma.j.issn.0366-6999.2012.13.011
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发表时间：
2012-07-05
影响因子：
6.1
通讯作者：
Yang Li
中科院分区：
文献类型：
--
作者：
Chen Yong-liang;Chen Wen-bin;Yang Li
背景肝门部胆管癌是一种较难治愈的恶性肿瘤。本研究旨在观察流量控制的部分门静脉动脉化（PPVA）对慢性阻塞性黄疸小型猪肝切除术后肝再生的影响。然后进行联合半肝切除术，其模仿用于治疗肝门部胆管癌的扩大根治术。将8头小型猪随机分为A、B组，每组4头。A组行PPVA，B组未行PPVA。结果A组术后即刻和术后30 d门静脉PO 2均高于B组，P < 0. 05 B组分别为（47.33 ± 2.43）和（48.50 ± 4.44）mmHg（35.38 ± 4.06）和（35.55 ± 2.55）mmHg，均P
Background Hilar cholangiocarcinoma is a malignant tumor that is difficult to cure. The aim of this study was to observe the effects of flow-controlled partial portal vein arterializations (PPVA) on liver regeneration after hepatectomy in minipigs with chronic obstructive jaundice.Methods Eight minipigs were made into chronic obstructive jaundice models. United semi-hepatectomy, which imitates extended radical surgery for treatment of hilar cholangiocarcinoma, was then performed. The eight minipigs were randomly divided into groups A and B (n=4 minipigs each). PPVA was performed in Group A but not in Group B. The effects of flow-controlled PPVA on live regeneration after hepatectomy were observed for 30 days after hepatectomy.Results The portal vein PO2 at the immediate time point and on postoperative day 30 was higher in Group A ((47.33+/-2.43) and (48.50+/-4.44) mmHg) than in Group B ((35.38+/-4.06) and (35.55+/-2.55) mmHg respectively, all P