EFFECT OF PERIODIC ANTI-ASCARIS AND ANTI-GIARDIA TREATMENT ON NUTRITIONAL-STATUS OF PRESCHOOL-CHILDREN
EFFECT OF PERIODIC ANTI-ASCARIS AND ANTI-GIARDIA TREATMENT ON NUTRITIONAL-STATUS OF PRESCHOOL-CHILDREN
复制标题
DOI：
10.1093/ajcn/36.1.79
复制
发表时间：
1982-01-01
影响因子：
7.1
通讯作者：
URRUTIA, JJ
中科院分区：
文献类型：
--
作者：
GUPTA, MC;URRUTIA, JJ
儿童（159），年龄24-61个月。60%蛔虫病和21.5%贾第虫病的流行率在危地马拉农村进行了为期1年的前瞻性研究。他们被分为4组，年龄，性别，社会经济地位和过去的增长经验，判断年龄的身高和体重的斜率。每组随机分配到以下2个月。治疗方案：I组，安慰剂; II组，哌嗪; III组，甲硝唑; IV组，哌嗪和甲硝唑。每3个月测量一次身高和体重，每4个月检查一次粪便中的寄生虫。在研究结束时，服用噻嗪使蛔虫的患病率降低至33.8%，但生长保持不变。在研究结束时，甲硝哒唑给药将贾第虫病的患病率降低至2.5%，并伴随着由Δ重量，Δ年龄体重百分比，年龄体重斜率，Δ高度，Δ年龄身高百分比和年龄身高斜率。在本研究中，抗蛔虫治疗未能促进生长可能是因为受试者没有严重营养不良，膳食蛋白质充足，可能的低蠕虫负荷，以及未能根除蛔虫。贾第虫病与学龄前儿童生长发育迟缓明显相关。
Children (159) aged 24-61 mo. with 60% ascariasis prevalence and 21.5% giardiasis prevalence in rural Guatemala were studied prospectively for 1 yr. They were divided into 4 groups comparable for age, sex, socioeconomic status, and past growth experience as judged by slopes of height and weight on age. Each group was randomly assigned to the following 2-mo. treatment regimens: group I, placebo; group II, piperazine; group III, metronidazole; group IV, piperazine and metronidazole. Height and weight were measured every 3 months and stools were examined for parasites every 4 months. Piperazine administration decreased the prevalence of ascariasis to 33.8% at the end of the study but growth remained unaltered. Metronidazole administration decreased the prevalence of giardiasis to 2.5% at the end of the study and was accompanied by increased growth as judged by .DELTA. weight, .DELTA. percent weight for age, slope of weight on age, .DELTA. height, .DELTA. percent height for age and slope of height on age. Failure of antiascaris treatment to enhance growth in this study may be because of absence of severe malnutrition in the subjects, adequacy of dietary protein; possible low worm load, and failure to eradicate ascariasis. Giardiasis is evidently associated with reduced growth in preschool children.