Mapping the EORTC QLQ C-30 onto the EQ-5D Instrument: The Potential to Estimate QALYs without Generic Preference Data
Mapping the EORTC QLQ C-30 onto the EQ-5D Instrument: The Potential to Estimate QALYs without Generic Preference Data
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DOI：
10.1111/j.1524-4733.2008.00405.x
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发表时间：
2009-01-01
期刊：
影响因子：
4.5
通讯作者：
van der Pol, Marjon
中科院分区：
文献类型：
--
作者：
McKenzie, Lynda;van der Pol, Marjon
本文的目的是将欧洲癌症研究和治疗组织（EORTC） QLQ C-30映射到EQ-5D度量，从而能够基于EORTC QLQ C-30数据估计健康状态值。EORTC QLQ C-30之所以引起人们的兴趣，是因为它是衡量癌症患者生活质量的最常用仪器。回归分析是用来建立两个工具之间的关系。该模型的性能是根据对EORTC QLQ C-30的反应对单独数据集的EQ-5D反应的预测程度来评估的。结果表明，该模型对EQ-5D值具有较好的预测效果。所有的实际值都在预测值的95%置信区间内。更重要的是，两组试验中质量调整生命年（QALYs）的预测差异与实际差异几乎相同。通过对疾病特异性EORTC QLQ C-30生活质量测量的反应，有可能估计EQ-5D值。这种可能性意味着，在不包括疾病特异性测量的研究中，仍有可能估计质量aly。
The aim of this article is to map the European Organization for Research and Treatment of Cancer (EORTC) QLQ C-30 onto the EQ-5D measure to enable the estimation of health state values based on the EORTC QLQ C-30 data. The EORTC QLQ C-30 is of interest because it is the most commonly used instrument to measure the quality of life of cancer patients.Regression analysis is used to establish the relationship between the two instruments. The performance of the model is assessed in terms of how well the responses to the EORTC QLQ C-30 predict the EQ-5D responses for a separate data set.The results showed that the model explaining EQ-5D values predicted well. All of the actual values were within the 95% confidence intervals of the predicted values. More importantly, predicted difference in quality-adjusted life-years (QALYs) between the arms of the trial was almost identical to the actual difference.There is potential to estimate EQ-5D values using responses to the disease-specific EORTC QLQ C-30 measure of quality of life. Such potential implies that in studies that do not include disease-specific measures, it might still be possible to estimate QALYs.