Enhancement of acyl coenzyme A:retinol acyltransferase in rat liver and mammary tumor tissue by retinyl acetate and its competitive inhibition by N-(4-hydroxyphenyl) retinamide.
Enhancement of acyl coenzyme A:retinol acyltransferase in rat liver and mammary tumor tissue by retinyl acetate and its competitive inhibition by N-(4-hydroxyphenyl) retinamide.
复制标题
乙酸视黄酯对大鼠肝脏和乳腺肿瘤组织中酰基辅酶A：视黄醇酰基转移酶的增强作用以及N-(4-羟苯基)视黄酰胺对其的竞争性抑制作用。
DOI：
10.1016/0006-291x(85)91636-5
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发表时间：
1985
影响因子：
3.1
通讯作者：
Olson,JA
中科院分区：
文献类型：
--
作者：
Ball,MD;Furr,HC;Olson,JA
在大鼠乳腺肿瘤和肝组织中，通过微粒体酰基辅酶A：视黄醇酰基转移酶对视黄醇酯化进行定量。乳腺癌大鼠肝脏酰基转移酶活性为正常动物的40%。每日口服2 mg醋酸视黄酯18-19天后，移植大鼠乳腺肿瘤的活性增加2.8倍，荷瘤大鼠肝脏的活性增加4.1倍，正常大鼠肝脏的活性增加1.5倍。全反式-N-（4-羟基苯基）视黄酰胺（Kj= 154 μM）可竞争性抑制视黄醇的体外酯化反应。
Retinol esterification by microsomal acyl coenzyme A:retinol acyltransferase was quantified in rat mammary tumor and liver tissue. Acyltransferase activity in the livers of mammary tumor-bearing rats was 40% of that in normal animals. In response to daily oral doses of 2 mg retinyl acetate for 18–19 days, activity increased 2.8-fold in transplanted rat mammary tumors, 4.1-fold in the livers of tumor-bearing rats, and 1.5-fold in the livers of normal rats. Thein vitroesterification of retinol was competitively inhibited by all-trans-N-(4-hydroxyphenyl)retinamide (Kj= 154 μM).