A Thermoresponsive Membrane for Chiral Resolution
A Thermoresponsive Membrane for Chiral Resolution
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DOI：
10.1002/adfm.200700534
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发表时间：
2008-02
影响因子：
19
通讯作者：
Mei-Jia Yang;L. Chu;Haidong Wang;Rui Xie;Hang Song;C. Niu
中科院分区：
文献类型：
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作者：
Mei-Jia Yang;L. Chu;Haidong Wang;Rui Xie;Hang Song;C. Niu
研制了一种新型的高性能手性热响应膜。该膜表现出基于β -环糊精（β - CD）分子识别的手性选择性和基于聚N -异丙基丙烯酰胺（PNIPAM）相变的热敏性。采用等离子体接枝填充聚合法将线性PNIPAM链接枝到多孔尼龙6膜基底上；因此，这些链作为β - CD分子的微环境调节剂。通过化学接枝聚合方法将β - CD基团引入到PNIPAM链中，并作为手性选择器。接枝的PNIPAM链的相变影响了β - CD分子的微环境，从而影响了β - CD与客体分子之间的结合。所制备的热敏膜在低于PNIPAM低临界溶液温度（LCST）的条件下进行手性拆分时的手性选择性高于无热敏膜。此外，负载对映体的热响应膜在温度高于最低温度时的解丛率远高于无热敏性的膜。因此，通过简单地改变操作温度，高，选择性的手性分辨率和高效的膜再生实现。该膜为解决难解的手性固体膜提供了一种新的、有效的方法，对手性拆分具有很大的吸引力。
A novel thermoresponsive membrane for chiral resolution with high performance has been developed. The membrane exhibits chiral selectivity based on molecular recognition of beta‐cyclodextrin (β‐CD) and thermosensitivity based on the phase transition of poly(N‐isopropylacrylamide) (PNIPAM). Linear PNIPAM chains were grafted onto porous nylon‐6 membrane substrates by using a plasma‐graft pore‐filling polymerization method; the chains thus acted as microenvironmental adjustors for β‐CD molecules. β‐CD moieties were introduced into the linear PNIPAM chains by a chemical grafting polymerization method and acted as chiral selectors. The phase transition of grafted PNIPAM chains affects the microenvironment of β‐CD molecules and, thus, the association between β‐CD and guest molecules. The chiral selectivity of the prepared thermoresponsive membranes in chiral resolution operated at temperature below the lower critical solution temperature (LCST) of PNIPAM is higher than that of membranes with no thermosensitivity. Furthermore, the decomplexation ratio of enantiomer‐loaded thermoresponsive membranes in decomplexation at temperatures above the LCST is much higher than that of membranes with no thermosensitivity. Thus, by simply changing the operation temperature, high, selective chiral resolution and efficient membrane regeneration are achieved. The proposed membrane provides a new and efficient way to solve the difficult decomplexation problem of chiral solid membranes, which is highly attractive for chiral resolution.