Dosiomic feature comparison between dose-calculation algorithms used for lung stereotactic body radiation therapy
Dosiomic feature comparison between dose-calculation algorithms used for lung stereotactic body radiation therapy
复制标题
DOI：
10.1007/s12194-022-00651-9
复制
发表时间：
2022-01-24
影响因子：
1.6
通讯作者：
Mizowaki, Takashi
中科院分区：
文献类型：
--
作者：
Adachi, Takanori;Nakamura, Mitsuhiro;Mizowaki, Takashi
评价肺立体定向体部放射治疗（SBRT）剂量计算算法之间基于剂量的放射组学（剂量组学）特征的再现性。我们分析了2011年3月至2017年12月期间接受肺SBRT的105例早期非小细胞肺癌患者。4 - 8、60和70戈伊的辐射剂量分4-8次照射到等中心点。在iPlan放射治疗计划系统（RTPS）上使用X射线体素蒙特卡罗（XVMC）进行剂量计算。此后，在Eclipse RTPS上使用Acuros XB（AXB）和分析各向异性算法（AAA）重新计算辐射剂量，同时保持XVMC计算的监测器单位和射束排列。共提取6808剂量学特征没有预处理（112形状，144一阶，600纹理特征）或小波滤波器8分解（1152一阶和4800纹理特征）。具有绝对成对一致相关系数的特征-|CCcon|- 超过或等于0.85的值被认为是高度可再现的。考虑小波滤波器和处方剂量进行亚组分析。XVMC-AXB、XVMC-AAA和AXB-AAA对的高度可重复的一阶和纹理特征的数量分别为34.8%、26.9%和31.0%。平均值之间的最大差异|CCcon|小波滤波器和处方剂量的亚组分析值分别为0.70和0.11。当使用不同类型的肺SBRT剂量计算算法时，基于小波滤波的剂量组学分析的应用可能受到限制。
To evaluate the reproducibility of dose-based radiomic (dosiomic) features between dose-calculation algorithms for lung stereotactic body radiation therapy (SBRT). We analyzed 105 patients with early-stage non-small cell lung cancer who underwent lung SBRT between March 2011 and December 2017. Radiation doses of 48, 60, and 70 Gy were prescribed to the isocenter in 4-8 fractions. Dose calculations were performed using X-ray voxel Monte Carlo (XVMC) on the iPlan radiation treatment planning system (RTPS). Thereafter, the radiation doses were recalculated using the Acuros XB (AXB) and analytical anisotropic algorithm (AAA) on the Eclipse RTPS while maintaining the XVMC-calculated monitor units and beam arrangements. A total of 6808 dosiomic features were extracted without preprocessing (112 shape, 144 first-order, and 600 texture features) or with wavelet filters to eight decompositions (1152 first-order and 4800 texture features). Features with absolute pairwise concordance correlation coefficients-|CCcon|-values exceeding or equaling 0.85 were considered highly reproducible. Subgroup analyses were performed considering the wavelet filters and prescribed doses. The numbers of highly reproducible first-order and texture features were 34.8%, 26.9%, and 31.0% for the XVMC-AXB, XVMC-AAA, and AXB-AAA pairs, respectively. The maximum difference between the mean |CCcon| values was 0.70 and 0.11 for the subgroup analyses of wavelet filters and prescribed dose, respectively. The application of wavelet filter-based dosiomic analyses may be limited when using different types of dose-calculation algorithms for lung SBRT.