Biomonitoring of 20 trace elements in blood and urine of occupationally exposed workers by sector field inductively coupled plasma mass spectrometry
Biomonitoring of 20 trace elements in blood and urine of occupationally exposed workers by sector field inductively coupled plasma mass spectrometry
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DOI：
10.1016/j.talanta.2013.07.079
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发表时间：
2013-11-15
期刊：
影响因子：
6.1
通讯作者：
Drobyshev, E. J.
中科院分区：
文献类型：
--
作者：
Ivanenko, N. B.;Ivanenko, A. A.;Drobyshev, E. J.
建立了扇形场电感耦合等离子体质谱法测定全血和尿液中Ag、Al、As、Ba、Be、Cd、Co、Cr、Cs、Cu、Fe、Mn、Ni、Pb、Se、Sr、Tl、U、V和Zn的方法。微波辅助消解与浓硝酸用于血液样品。用5%（v/v）硝酸1/50（v/v）稀释后分析尿样。对于铍，显示了中等分辨率模式（R=4000）的必要性。使用血液和尿液参比物质并通过分析加标样品进行方法验证。对于所设计的方法，浓度范围0.01-1.0 μ g/L的相对标准偏差（RSD）为5- 10%。当微量元素浓度大于1.0 μ g/L时，RSD不超过3%。方法检测限（3 sigma）：Ag 0.7 ng/L，Al 16 ng/L，As 3.4 ng/L，Ba 0.02 ng/L，Be 1.5 ng/L，Cd 7.7 ng/L，Co 1.0 ng/L，Cr 2.8 ng/L，Cs 9.8 ng/L，Cu 27 ng/L，Fe 1.1 ng/L，Mn 1.8 ng/L，Ni 17 ng/L，Pb 13 ng/L，Se 0.07 ng/L，锶5.7 ng/L、铊0.2 ng/L、铀0.1 ng/L、钒0.7 ng/L、锌1.2 ng/L。为了进行初步风险评估，采用电感耦合等离子体发射光谱法对技术表面粉尘进行了分析。根据50份血液和40份尿液样本的分析结果，进行了职业接触评价。发现暴露风险未超过可接受范围。发现Be和Al、Cr、Mn可能存在健康危害。作为当前调查的结果，发布了生物监测企业医疗保健单位的职业健康和安全建议。(C)2013爱思唯尔有限公司版权所有。
A sector field inductively coupled plasma mass spectrometry method for the determination of Ag, Al, As, Ba, Be, Cd, Co, Cr, Cs, Cu, Fe, Mn, Ni, Pb, Se, Sr, Tl, U, V and Zn in whole blood and urine was designed. Microwave-assisted digestion with concentrated nitric acid was used for blood samples. Urine samples were analyzed after 1/50 (v/v) dilution with 5% (v/v) nitric acid. For beryllium the necessity of medium resolution mode (R=4000) was shown. Method validation was performed using blood and urine reference materials and by analyzing of spiked samples. For the designed method relative standard deviation (RSD) for the concentration range 0.01-1.0 mu g/L was 5-10%. RSD did not exceed 3% when trace elements concentrations were above 1.0 mu g/L. Method detection limits (3 sigma): Ag 0.7 ng/L, Al 16 ng/L, As 3.4 ng/L, Ba 0.02 ng/L, Be 1.5 ng/L, Cd 7.7 ng/L, Co 1.0 ng/L, Cr 2.8 ng/L, Cs 9.8 ng/L, Cu 27 ng/L, Fe 1.1 ng/L, Mn 1.8 ng/L, Ni 17 ng/L, Pb 13 ng/L, Se 0.07 ng/L, Sr 5.7 ng/L, Tl 0.2 ng/L, U 0.1 ng/L, V 0.7 ng/L and Zn 1.2 ng/L.A developed method was applied for trace element biomonitoring of occupationally exposed workers of a beryllium processing enterprise. For preliminary risk assessment technological surface dust had been analyzed by inductively coupled plasma optical emission spectrometry. Based upon results of 50 blood and 40 urine samples analyses occupational exposure evaluation was performed. Exposure risks were found not to exceed acceptable ranges. Possible health hazards were found for Be and also Al, Cr, Mn. Occupational health and safety recommendations for the biomonitored enterprise medical care unit were issued as a result of the current investigation. (C) 2013 Elsevier B.V. All rights reserved.