Elevated alanine aminotransferase is strongly associated with incident metabolic syndrome: a meta-analysis of prospective studies.
Elevated alanine aminotransferase is strongly associated with incident metabolic syndrome: a meta-analysis of prospective studies.
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丙氨酸氨基转移酶升高与代谢综合征密切相关：前瞻性研究的荟萃分析。
DOI：
10.1371/journal.pone.0080596
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Peng T
中科院分区：
文献类型：
--
作者：
Liu Z;Que S;Ning H;Wang L;Peng T
代谢综合征（MetS）的发病率在全球范围内迅速增加，并与丙氨酸氨基转移酶（ALT）活性相关。然而，ALT活性对MetS发生率的影响在已发表的文献中不一致。因此，我们通过前瞻性队列研究的荟萃分析，估计ALT活性升高与MetS事件之间的关联。从Pubmed、Embase和科学信息研究所（ISI）检索了所有已发表的关于ALT活性升高与MetS事件之间相关性的前瞻性队列研究。总共招募了7项前瞻性队列研究，31545名参与者和2873例偶发MetS。如果存在不显著的异质性（P值>0.05且I2<50%），则使用固定效应模型计算由ALT升高诱导的偶发MetS的合并相对风险（RR）。否则，使用随机效应模型。当比较ALT活性最高与最低分类之间的MetS发生率时，计算的RR为1.81（95%置信区间[CI]：1.49-2.14）。在剂量反应分析中，ALT增量为5单位/升（U/l）时，合并RR为1.13（95%CI：1.11-1.16）。亚组分析表明，性别差异可能是总体分析异质性的主要来源（在ALT增量为5 U/l的情况下评价的性别特异性亚组RR之间P=0.007）。 女性MetS发病率的剂量反应风险（1.38，95% CI：1.20-1.55）高于男性。敏感性分析证实了结果的稳定性。在我们的荟萃分析中没有发现发表偏倚。目前来自前瞻性研究的证据支持ALT升高与MetS发病率增加之间的关联。这种关联在女性人群中更为紧密和一致。需要进一步的研究来证实这种关联，并调查ALT活性对MetS发生的潜在机制。
The incidence of metabolic syndrome (MetS) is rapidly increasing worldwide and associated with alanine aminotransferase (ALT) activity. However, the impact of ALT activity on MetS incidence is inconsistent in published literature. We therefore estimated the association between elevated ALT activity and incident MetS through a meta-analysis of prospective cohort studies. All published prospective cohort studies on the association between elevated ALT activity and incident MetS were retrieved from Pubmed, Embase, and the Institute for Scientific Information (ISI). In all, seven prospective cohort studies, with 31545 participants and 2873 cases of incident MetS were recruited. If there was insignificant heterogeneity (P-value>0.05 and I2<50%), the fixed-effect model was used to calculate the pooled relative risks (RRs) of incident MetS induced by raised ALT. Otherwise, the random-effect model was used. The calculated RR was 1.81 (95% confidence interval [CI]: 1.49–2.14) when the incidence of MetS was compared between the highest versus the lowest classification of ALT activities. The pooled RR was 1.13 (95% CI: 1.11–1.16) in dose-response analysis with 5 units per liter (U/l) of ALT increment. Subgroup analysis suggested that gender disparity might be the main origin of heterogeneity in overall analysis (P = 0.007 between RRs of gender-specific subgroups evaluated with 5 U/l increments of ALT). Women had a higher dose-response risk of MetS incidence (1.38, 95% CI: 1.20–1.55) than men. Furthermore, sensitivity analysis confirmed the stability of results. No publication bias was found in our meta-analysis. Current evidence from prospective studies supports the association between ALT elevation and increasing MetS incidence. This association is closer and more consistent in female population. Further studies are needed to confirm this association and to investigate the potential mechanism of ALT activity on MetS occurrence.
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DOI：
10.1046/j.1440-1746.2000.02124.x
发表时间：
2000-05-01
影响因子：
4.1
作者：
Chen, CJ;Wang, LY;Yu, MW
通讯作者：
Yu, MW
影响因子：
37.8
作者：
Cheng S;Rhee EP;Larson MG;Lewis GD;McCabe EL;Shen D;Palma MJ;Roberts LD;Dejam A;Souza AL;Deik AA;Magnusson M;Fox CS;O'Donnell CJ;Vasan RS;Melander O;Clish CB;Gerszten RE;Wang TJ
通讯作者：
Wang TJ
DOI：
10.1111/j.1440-1746.2006.04615.x
发表时间：
2007-09-01
影响因子：
4.1
作者：
Chen, Chien-Hua;Huang, Min-Ho;Yueh, Sen-Kou
通讯作者：
Yueh, Sen-Kou
影响因子：
5
作者：
GREENLAND, S;LONGNECKER, MP
通讯作者：
LONGNECKER, MP
影响因子：
13.5
作者：
Browning, JD;Szczepaniak, LS;Hobbs, HH
通讯作者：
Hobbs, HH