Near-Infrared Spectra in Buccal Tissue as a Marker for Detection of Hypoxia
Near-Infrared Spectra in Buccal Tissue as a Marker for Detection of Hypoxia
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DOI：
10.3357/amhp.4510.2016
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发表时间：
2016-05-01
影响因子：
0.9
通讯作者：
Mirtaheri, Peyman
中科院分区：
文献类型：
--
作者：
Amini, Maryam;Hisdal, Jonny;Mirtaheri, Peyman
简介：高原暴露引起的缺氧会损害大脑和精神功能。颊组织的血流量和氧合可以作为检测缺氧的可靠标志。在本研究中，近红外光谱与新型光学探针结合使用，评估新型探针在缺氧条件下测量口腔组织缺氧标记物的适用性。 方法：六名健康参与者在海拔 2000 至 16,000 英尺的低压室内进行测试。血流量和氧饱和度的颊参考测量值与新型近红外探头的光谱测量值同步，并通过多元偏最小二乘法评估参考测量值和光谱数据之间的关系。此外，实验过程中还测量了手指血氧饱和度，并将记录结果与颊氧饱和度进行了比较。结果：光谱分析表明，近红外探头的光谱数据与反射传感器测量的颊血流和氧合的吸收特征密切相关（平均R-2 = 0.89）。结果表明，与手指血氧饱和度相比，参考脉搏血氧仪记录的颊氧饱和度可能被高估，平均差值从1.8%增加到1.8%。 2000 英尺处为 16,000 英尺处的 11.4%。结论：新型近红外探头在同时测量颊组织中的血流量和氧饱和度方面显示出有希望的结果。建议的方法可以作为未来临床应用中缺氧早期指示的新技术。
INTRODUCTION: Hypoxia caused by high altitude exposure can impair cerebral and mental functions. Blood flow and oxygenation of the buccal tissue can be reliable markers to detect hypoxia. In this study, near infrared spectroscopy was used in combination with a novel optical probe to evaluate the applicability of the novel probe in measuring hypoxia markers in buccal tissue under a hypoxic condition.METHODS: Six healthy participants were tested at altitudes from 2000 to 16,000 ft inside a hypobaric chamber. The buccal reference measurements of blood flow and oxygen saturation were synchronized with the spectral measurements of the novel near infrared probe and the relationship between the reference measurements and spectral data were evaluated by multivariate partial least square method. In addition, finger oxygen saturation was measured during the experiment and the recordings were compared with buccal oxygen saturation.RESULTS: The spectral analysis illustrated that the spectral data from the near infrared probe correlated strongly with the absorption features of both buccal flow and oxygenation measured by the reflectance sensors (average R-2 = 0.89).The results showed probably overestimated values for buccal oxygen saturation recorded by the reference pulse oximeter in comparison with finger oxygen saturation, with the mean difference increasing from 1.8% at 2000 ft to 11.4% at 16,000 ft.CONCLUSION: The novel near infrared probe showed promising results for simultaneous measurement of blood flow and oxygen saturation in the buccal tissue. The suggested method can be used as a new technique for early indication of hypoxia in future clinical applications.