The Effect of Etomoxir on Glucose Turnover and Recycling with [1-14C], [3-3H]-Glucose Tracer in Pigs
The Effect of Etomoxir on Glucose Turnover and Recycling with [1-14C], [3-3H]-Glucose Tracer in Pigs
复制标题
依托莫昔尔对猪体内葡萄糖周转和[1-14C]、[3-3H]-葡萄糖示踪剂回收的影响
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
K. Brenner
中科院分区：
文献类型：
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作者：
H. Wolf;K. Brenner
4头禁食猪注射依托莫西后，血糖浓度显著下降(48%)。为了评估肝脏葡萄糖生成抑制或外周葡萄糖利用增加是否存在因果关系，采用预先输注[3-~3H]-葡萄糖和[1-14C]-葡萄糖，并测定葡萄糖的转化率、葡萄糖的循环和代谢清除率。输注依托莫西对葡萄糖转换率无明显影响。葡萄糖碳的循环受到的影响相对较小。代谢清除率从对照组的5.0+/-0.7ml/kg×min增加到治疗组的11.3+/-3.5ml/kg×min(均值+/-扫描电子显微镜；P<0.05)。我们的结论是，在禁食条件下，葡萄糖利用率的增加在依托莫西的降血糖作用中起着重要作用。
Infusion of etomoxir to 4 fasted pigs caused significant (48%) falls in blood glucose concentrations. To assess whether inhibition of hepatic glucose production or increase of peripheral glucose utilisation is causally associated, a primed infusion of [3-3H]-glucose and [1-14C]-glucose was used, and glucose turnover rates, recycling and metabolic clearance rate of glucose were determined. No effects of infusion of etomoxir on glucose turnover rates could be found. Recycling of glucose carbon was affected to a relatively small extent. The metabolic clearance rate, however, increased by 126% from 5.0 +/- 0.7 ml/kg x min in the control group to 11.3 +/- 3.5 ml/kg x min in the treated group (mean +/- SEM; P less than 0.05). We conclude that under fasting conditions an increase in glucose utilization plays a major part in the blood glucose lowering effect of etomoxir.
影响因子：
15.9
作者：
FERRANNINI, E;BARRETT, EJ;DEFRONZO, RA
通讯作者：
DEFRONZO, RA