Myeloneuropathy and anemia due to copper malabsorption
Myeloneuropathy and anemia due to copper malabsorption
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DOI：
10.1007/s00415-004-0428-x
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发表时间：
2004-06-01
影响因子：
6
通讯作者：
Low, PA
中科院分区：
文献类型：
--
作者：
Kumar, N;Low, PA
饮食中铜的缺乏会导致反刍动物的进行性共济性脊髓病。门克斯病是一种人类疾病，由于铜吸收的遗传性缺陷；通常不知道是否会存活到成年。我们报告了一位63岁的女性，她被我们评估为在铜吸收不良的情况下发生的髓神经病变。她的神经退化在补充铜后停止了。关于获得性铜缺乏的神经学表现的有限文献表明，其临床表现类似于维生素B12缺乏所见的髓神经病变。
Dietary deficiency of copper results in a progressive ataxic myelopathy in ruminants called swayback. Menkes disease is a human disease due to an inherited defect in copper absorption; survival into adulthood is typically not known to occur. We report a 63-year-old woman who was evaluated by us for a myeloneuropathy that occurred in the setting of copper malabsorption. Her neurological deterioration stopped with copper supplementation. The limited literature on neurological manifestations of acquired copper deficiency suggests that the clinical presentation resembles the myeloneuropathy seen with vitamin B12 deficiency.