Piezoelectric and photothermal dual functional film for enhanced dermal wound regeneration via upregulation of Hsp90 and HIF-1α
Piezoelectric and photothermal dual functional film for enhanced dermal wound regeneration via upregulation of Hsp90 and HIF-1α
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DOI：
10.1016/j.apmt.2020.100756
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发表时间：
2020-09-01
影响因子：
8.3
通讯作者：
Li, Xiaokun
中科院分区：
文献类型：
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作者：
Chen, Yanxin;Ye, Mengqi;Li, Xiaokun
皮肤伤口，特别是慢性伤口，如压力和糖尿病溃疡，正在对全球医疗保健系统构成巨大威胁。因此，现在非常需要实现有效伤口治疗的新策略。在此，我们是第一个报告的组合疗法的电刺激和热的伤口愈合，只是使用一个简单的压电和光热双功能薄膜。该膜被命名为CM@DA，简单地通过在壳聚糖膜上涂覆聚多巴胺来制造。CM@DA在机械压力下产生电压，并在近红外（NIR）光照射下显示光热效应。在大鼠全层创面模型的体内实验中，由于在创面上产生电刺激和热，因此具有NIR的CM@DA可以有效地促进创面再生。进一步研究了CM@DA的愈合机制，结果表明CM@DA通过热休克蛋白90（Hsp 90）和缺氧诱导因子1 α（HIF-1 α）参与的途径促进伤口愈合。这些结果表明，CM@DA是未来临床应用的有希望的伤口敷料候选者。(c)2020爱思唯尔有限公司保留所有权利。
Skin wounds, especially chronic wounds such as pressure and diabetic ulcers, are posing a huge threat to healthcare systems worldwide. Thus, novel strategies to realize effective wound therapy are nowadays extremely needed. Herein, we are the first to report a combination therapy of electric stimulation and heat for wound healing just using a facile piezoelectric and photothermal dual functional film. The film, name as CM@DA, is simply fabricated by coating polydopamine on a chitosan film. CM@DA generates electric voltages under mechanical pressure and shows photothermal effect with irradiation of near-infra red (NIR) light. In vivo experiment with rat full-thickness wound model validates that CM@DA with NIR can effectively promote wound regeneration due to the generation of electric stimulation and heat on wounds. The healing mechanism of CM@DA is further investigated, and the result demonstrates that CM@DA enhances wound healing through a pathway in which heat shock protein 90 (Hsp90) and hypoxia-inducible factor 1 alpha (HIF-1 alpha) participate. These results indicate that CM@DA is a promising wound dressing candidate for clinical application in the future. (c) 2020 Elsevier Ltd. All rights reserved.