Brain SPECT imaging in children and adolescents with obsessive-compulsive disorder
Brain SPECT imaging in children and adolescents with obsessive-compulsive disorder
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DOI：
10.1007/s00702-004-0240-x
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发表时间：
2005-08-01
影响因子：
3.3
通讯作者：
Latorre, MRDD
中科院分区：
文献类型：
--
作者：
Castillo, ARGL;Buchpiguel, CA;Latorre, MRDD
目的：目的：应用脑SPECT显像评价儿童和青少年强迫症（OCD）治疗前后皮质和皮质下局部脑血流（rCBF）的变化。方法：对14例强迫症患者（6 ~ 17岁）进行脑SPECT检查，其中10例治疗成功后复查。对14例症状状态患者的rCBF比值与临床参数进行相关性分析，并对10例患者治疗前后的rCBF比值进行比较。有显着的临床相关性，目前的年龄和年龄的发病强迫症和rCBF在双边上级额叶，双侧顶叶皮质regions.Conclusions：进一步调查异常的神经发育的皮质-皮质下回路可能参与儿科强迫症的神经病学是必要的。
Objective: To evaluate the patterns of regional cerebral blood flow (rCBF) in cortical and subcortical regions by Brain SPECT imaging, in children and adolescents with obsessive-compulsive disorder (OCD) before and after treatment.Method: Fourteen OCD patients (6 to 17 years old) underwent brain SPECT; ten of those subjects were reexamined after successful treatment. rCBF ratios were correlated with clinical parameters on the 14 patients in symptomatic state, and we compared rCBF ratios of the ten patients before and after treatment.Results: There was no statistically significant difference in average ratios of rCBF before and after treatment. There were significant clinical correlations between current age and age of onset of OCD and rCBF in the bilateral superior frontal, and bilateral parietal cortical regions.Conclusions: Further investigations on abnormal neurodevelopment of cortical-subcortical circuits possibly involved in symptomatology of paediatric OCD are warranted.