Conservation of gene order: a fingerprint of proteins that physically interact

Conservation of gene order: a fingerprint of proteins that physically interact
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DOI:
10.1016/s0968-0004(98)01274-2
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发表时间:
1998-09-01
影响因子:
13.8
通讯作者:
Bork, P
Bork, P
中科院分区:
生物学1区
文献类型:
--
作者:
Dandekar, T;Snel, B;Bork, P

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对9个细菌和古菌基因组进行的系统比较显示,基因顺序(以及操纵子结构)的保守性程度较低。然而,一些基因对是保守的。由保守基因对编码的蛋白质似乎存在物理相互作用。因此,这一观察结果可用于预测原核基因产物的功能以及它们之间的相互作用。
A systematic comparison of nine bacterial and archaeal genomes reveals a low level of gene-order (and operon architecture) conservation. Nevertheless, a number of gene pairs are conserved. The proteins encoded by conserved gene pairs appear to interact physically. This observation can therefore be used to predict functions of, and interactions between, prokaryotic gene products.