[Changes in Mg++ concentration of CSF after subarachnoid hemorrhage and Mg++--effects on the contractions of bovine cerebral artery].
[Changes in Mg++ concentration of CSF after subarachnoid hemorrhage and Mg++--effects on the contractions of bovine cerebral artery].
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蛛网膜下腔出血后脑脊液镁浓度变化及镁对牛大脑动脉收缩的影响
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
K. Miura
中科院分区：
文献类型：
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作者：
K. Miura
15例蛛网膜下腔出血(SAH)患者分为两组，8例在出血后2~3周内出现血管痉挛(VS)(VS-组)，7例无血管痉挛(NS-组)。VS组患者脑脊液中[mg++]在出血后第6~8天由1.15 mm降至0.95 mm，差异有统计学意义，而NS组患者脑脊液中[mg++]无明显变化。两组脑脊液[Ca++]相对变化不大。VS-组的脑脊液[mg++]下降与其血液中[mg++]的下降无关。可能是由于实际出血部位附近的血-脑脊液屏障局部紊乱所致。体外实验检测了脑脊液中如此微小的[mg++]浓度的降低是否真的会影响血管痉挛的发生。利用牛大脑中动脉螺旋条，在多导生理记录仪上记录等长收缩时肌张力的变化。高钾(4×10~(-2)M)、前列腺素F2α(10~(-6)M)和氧合血红蛋白(Oxy-Hb，3×10~(-6)M)引起的血管收缩在灌注液浓度从1.2 mm降低到0.9 mm时增强，当浓度增加到2.4 mm时抑制作用。从大到小，[Mg++]在Oxy-Hb-、高K+-和PGF2α诱导的收缩中的作用更大。
Fifteen patients with subarachnoid hemorrhage (SAH) were divided into two groups; eight patients exhibiting vasospasm (VS) (VS-group), and another seven patients exhibiting no vasospasm (NS-group) during a period of 2-3 weeks after the occurrence of hemorrhage. The cerebrospinal fluid (CSF) of the patients in the VS-group demonstrated a slight but significant decrease in [Mg++] from 1.15 to 0.95 mM on the 6-8th day after the hemorrhage, whereas CSF in the NS-group showed no significant change in [Mg++]. CSF [Ca++] remained relatively unchanged in both groups. The decrease in CSF [Mg++] in the VS-group was not associated with a decrease in [Mg++] in their blood. Probably, it was due to local derangement of the blood-CSF barrier near the site of the actual hemorrhage. Whether or not such a small decrease in CSF [Mg++] could actually influence the occurrence of vasospasm was examined experimentally in vitro. Using helical strips of the bovine middle cerebral arteries, the changes in muscular tension during isometric contraction were recorded on the polygraph. Generally the vascular contractions induced by High K+ (4 X 10(-2) M), PGF2 alpha (10(-6) M), and Oxy-hemoglobin (Oxy-Hb, 3 X 10(-6) M) were augmented when [Mg++] of the perfusing media was reduced from 1.2 to 0.9 mM, and depressed when [Mg++] was increased to 2.4 mM. In descending order, a greater effect of [Mg++] was seen in Oxy-Hb-, and in High K+-, and PGF2 alpha-induced contractions.(ABSTRACT TRUNCATED AT 250 WORDS)