A Case of Delayed Emergence After Propofol Anesthesia: Genetic Analysis.
A Case of Delayed Emergence After Propofol Anesthesia: Genetic Analysis.
复制标题
异丙酚麻醉后苏醒延迟一例：遗传分析。
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
K. Sobue
中科院分区：
文献类型：
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作者：
H. Yonekura;N. Murayama;H. Yamazaki;K. Sobue
This case report describes a 71-year-old woman who experienced unusual delayed emergence from propofol, which lasted for 3 hours and resulted in admission to the intensive care unit. Because genetic variations of propofol-metabolizing enzymes are proposed to be causal factors, we explored genetic polymorphisms of cytochrome P450 2B6 (CYP2B6) and uridine 5'-diphospho-glucuronosyltransferase 1A9 (UGT1A9). Suggested high-risk factors (advanced age, CYP2B6 516 G/T, and UGT1A9 I399 C/C) were observed in this case of delayed propofol metabolism. Therefore, genetic variants involved in propofol metabolism should be considered in unexplained delayed emergence.
DOI：
10.1097/01.fpc.0000114754.08559.27
发表时间：
2004-08-01
期刊：
PHARMACOGENETICS
影响因子：
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作者：
Girard, H;Court, MH;Guillemette, C
通讯作者：
Guillemette, C