Osteopontin is a useful predictor of bone metastasis and survival in patients with locally advanced nasopharyngeal carcinoma
Osteopontin is a useful predictor of bone metastasis and survival in patients with locally advanced nasopharyngeal carcinoma
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DOI：
10.1002/ijc.29540
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发表时间：
2015-10-01
影响因子：
6.4
通讯作者：
Zhang, Li
中科院分区：
文献类型：
--
作者：
Hou, Xue;Wu, Xuan;Zhang, Li
骨是鼻咽癌（NPC）中最常见的转移部位。骨桥蛋白（OPN）和骨唾液酸蛋白（BSP）被证明与远处转移的多个步骤有关，并与癌症中的骨转移（BM）相关。我们旨在探讨OPN和BSP对局部晚期NPC患者预后的影响。生成了包括162个局部晚期NPC标本的组织微阵列进行免疫组织化学评估。所有患者都接受了治疗治疗。随访期间，有22名患者患有BM。 BM患者的OPN表达水平高于没有BM的患者（P = 0.005），而BSP表达水平没有显着差异（P = 0.634）。单变量分析表明，较高水平的OPN表达与较差的8年无转移生存率（MFS）率相关（P
Bone is the most common metastatic site in nasopharyngeal carcinoma (NPC). Osteopontin (OPN) and bone sialoprotein (BSP) are demonstrated to be involved in multiple steps of distant metastasis and correlate with bone metastasis (BM) in cancers. We aim to explore the impacts of OPN and BSP on the prognosis of the patients with locally advanced NPC. A tissue microarray including 162 locally advanced NPC specimens was generated for immunohistochemical evaluation. All of the patients received curative treatment. Twenty-two patients developed BM during follow-up. The OPN expression level was higher in patients with BM than in those without BM (p=0.005), whereas no significant difference of the BSP expression level was noted (p=0.634). Univariate analysis demonstrated that a higher level of OPN expression associated with a poorer 8-year metastasis-free survival (MFS) rate (p