PLASMA-LEVELS OF IL-1-BETA, TNF-ALPHA AND THEIR SPECIFIC INHIBITORS IN UNDIALYZED CHRONIC-RENAL-FAILURE, CAPD AND HEMODIALYSIS-PATIENTS
PLASMA-LEVELS OF IL-1-BETA, TNF-ALPHA AND THEIR SPECIFIC INHIBITORS IN UNDIALYZED CHRONIC-RENAL-FAILURE, CAPD AND HEMODIALYSIS-PATIENTS
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DOI：
10.1038/ki.1994.117
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发表时间：
1994-03-01
影响因子：
19.6
通讯作者：
DINARELLO, CA
中科院分区：
文献类型：
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作者：
PEREIRA, BJG;SHAPIRO, L;DINARELLO, CA
已证实在多种疾病中存在天然存在的白细胞介素-1（IL-1）和肿瘤坏死因子（TNF）抑制剂。IL-1受体拮抗剂（IL-1 Ra）与IL-1受体结合并阻断IL-1的活性，而可溶形式的p55 TNF受体（CTNFsRp 55）结合并中和TNF。本研究测定了29例慢性肾功能衰竭（CRF）未透析患者、13例持续非卧床腹膜透析（CAPD）患者、42例慢性血液透析（HD）患者和15例健康对照者的血浆IL-1 β、IL-1 Ra、TNF α和TNF sRp 55水平。在29例CRF患者中，13例患有终末期肾病（ESRD，估计GFR < 10 ml/min）。在健康对照组中，IL-1 β、IL-1 Ra和TNF α的血浆水平等于或低于测定的检测限。在未透析的ESRD患者中，或在CAPD或HD患者中，IL-1 β的血浆水平分别为428 +/- 134 pg/ml、378 +/- 83和352 +/- 43 pg/ml。虽然各组患者血浆IL-1 P水平均高于健康对照组（
The presence of naturally occurring inhibitors of interleukin-1 (IL-1) and tumor necrosis factor (TNF) in a variety of diseases has been demonstrated. The IL-1 receptor antagonist (IL-1Ra) binds to IL-1 receptors and blocks the activity of IL-1, and a soluble form of the p55 TNF receptor CTNFsRp55) binds and neutralizes TNF. In the present study, plasma levels of IL-1 beta, IL-1Ra, TNF alpha and TNFsRp55 were measured in 29 undialyzed patients with chronic renal failure (CRF), 13 patients on continuous ambulatory peritoneal dialysis (CAPD), 42 patients on chronic hemodialysis (HD) and in 15 healthy controls. Of the 29 patients with CRF, 13 had end-stage renal disease (ESRD, estimated GFR < 10 ml/min). Among healthy controls, plasma levels of IL-1 beta, IL-1Ra and TNF alpha were at or below the limit of detection of the assay. In undialyzed patients with ESRD, or in patients on CAPD or HD, plasma levels of IL-1 beta were 428 +/- 134 pg/ml, 378 +/- 83 and 352 +/- 43 pg/ml, respectively. Although plasma levels of IL-IP in each group of patients were higher than those in healthy controls (