Coffee intake and gastric cancer risk: the Singapore Chinese health study.
Coffee intake and gastric cancer risk: the Singapore Chinese health study.
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DOI：
10.1158/1055-9965.epi-13-0886
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发表时间：
2014-04
期刊：
影响因子：
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通讯作者：
Butler LM
中科院分区：
文献类型：
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作者：
Ainslie-Waldman CE;Koh WP;Jin A;Yeoh KG;Zhu F;Wang R;Yuan JM;Butler LM
尽管实验证据表明咖啡相关化合物对胃癌发生具有化学预防作用，但流行病学研究通常不支持咖啡与胃癌的关联。在经常喝咖啡的高风险人群中缺乏观察数据。我们在一个基于人群的队列中研究了含咖啡因咖啡摄入量与胃癌风险之间的关系，该队列在1993年至1998年期间在新加坡招募了63，257名45-74岁的中国男性和女性。在平均随访14.7年后，确定了胃癌病例（n=647）。幽门螺杆菌（Helicobacter pylori，H. pylori）感染的一个亚组中进行测量，所述亚组具有在癌症诊断之前收集的血液和其匹配的对照。在总队列中，每日与非每日咖啡摄入量与胃癌风险的统计学非显著性降低相关[风险比（HR）= 0.85; 95%置信区间（CI）：0.69，1.04）。在女性中，负相关加强并达到统计学显著性（HR=0.63; 95% CI：0.46，0.87）。在仅限于从不吸烟者和不饮酒者的分析中，总队列（HR=0.69; 95%CI：0.52，0.91）和女性（HR=0.52; 95%CI：0.37，0.74）中的负相关性增强。在男性中，咖啡与胃癌风险无关，无论吸烟状况或饮酒量如何。在巢式病例对照研究中，在校正H.幽门感染每天喝咖啡可以降低高危人群患胃癌的风险，尤其是女性。影响：旨在确定咖啡中可能防止胃癌发生的化合物的研究是必要的。
Despite experimental evidence showing chemopreventive effects of coffee-related compounds on gastric carcinogenesis, epidemiologic studies generally do not support coffee-gastric cancer associations. Observational data are lacking among high-risk populations with sufficient regular coffee consumption. We examined the association between caffeinated coffee intake and gastric cancer risk in a population-based cohort that enrolled 63,257 Chinese men and women aged 45–74 years between 1993 and 1998 in Singapore. Incident gastric cancer cases (n=647) were identified after a mean follow-up of 14.7 years. Biomarkers of Helicobacter pylori (H. pylori) infection were measured in a subset of gastric cancer cases with blood collected prior to cancer diagnosis and their matched controls. In the total cohort, daily versus non-daily coffee intake was associated with a statistically non-significant decrease in gastric cancer risk [hazards ratio (HR) = 0.85; 95% confidence interval (CI): 0.69, 1.04). In women, the inverse association strengthened and reached statistical significance (HR=0.63; 95% CI: 0.46, 0.87). In analyses restricted to never smokers and nondrinkers of alcohol, inverse associations strengthened in the total cohort (HR=0.69; 95% CI: 0.52, 0.91) and in women (HR=0.52; 95% CI: 0.37, 0.74). There was no coffee-gastric cancer risk association among men, regardless of smoking status or alcohol consumption. Similar results were observed in the nested case-control study after adjustment for H. pylori infection. Daily coffee consumption may reduce the risk of gastric cancer in high-risk populations, especially among women. Impact: Research aimed at identifying the compounds in coffee that may protect against gastric carcinogenesis is warranted.