Development from childhood to adulthood increases morphological and functional inter-individual variability in the right superior temporal cortex
Development from childhood to adulthood increases morphological and functional inter-individual variability in the right superior temporal cortex
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DOI：
10.1016/j.neuroimage.2013.07.017
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发表时间：
2013-12-01
期刊：
影响因子：
5.7
通讯作者：
Goebel, Rainer
中科院分区：
文献类型：
--
作者：
Bonte, Milene;Frost, Martin A.;Goebel, Rainer
本文研究了儿童（8-9岁）、青少年（14-15岁）和青年人上级颞叶皮层（SIC）的形态和功能发育轨迹。我们分析了皮质表面标志和功能磁共振成像（fMRI）对声音，其他自然类别和音调的反应，并研究了半球不对称性和受试者间变异性如何随年龄变化。我们的研究结果表明，稳定的形态不对称的年龄组，包括一个更大的左颞平面和更深的右上级颞沟。功能磁共振成像分析表明，声音选择性反应的单侧化存在于所有组中，但随着年龄的增长而减少。此外，SIC对声音的反应从儿童的选择性较低和空间扩散性更强转变为成人的高度选择性和焦点性。有趣的是，形态标志的分析表明，主体间的变异性增加，在发展过程中的权利-但不是在左- SIC。同样，在右侧SIC中，对声音、其他类别和音调的皮质重新排列的功能反应的受试者间变异性随着年龄的增长而增加。我们的研究结果揭示了听觉和声音感知的关键大脑区域的不对称发育变化。与年龄相关的增加主体间的变异性在右侧SIC表明，解剖和功能的这一地区是由独特的个人发展经验。(C)2013 Elsevier Inc. All rights reserved.
We study the developmental trajectory of morphology and function of the superior temporal cortex (SIC) in children (8-9 years), adolescents (14-15 years) and young adults. We analyze cortical surface landmarks and functional MRI (fMRI) responses to voices, other natural categories and tones and examine how hemispheric asymmetry and inter-subject variability change across age. Our results show stable morphological asymmetries across age groups, including a larger left planum temporale and a deeper right superior temporal sulcus. fMRI analyses show that a rightward lateralization for voice-selective responses is present in all groups but decreases with age. Furthermore, SIC responses to voices change from being less selective and more spatially diffuse in children to highly selective and focal in adults. Interestingly, the analysis of morphological landmarks reveals that inter-subject variability increases during development in the right - but not in the left - SIC. Similarly, inter-subject variability of cortically-realigned functional responses to voices, other categories and tones increases with age in the right SIC. Our findings reveal asymmetric developmental changes in brain regions crucial for auditory and voice perception. The age-related increase of inter-subject variability in right SIC suggests that anatomy and function of this region are shaped by unique individual developmental experiences. (C) 2013 Elsevier Inc. All rights reserved.