Neuronal loss in the hippocampus in Huntington's disease: a comparison with HIV infection.
Neuronal loss in the hippocampus in Huntington's disease: a comparison with HIV infection.
复制标题
DOI：
10.1136/jnnp.56.5.487
复制
发表时间：
1993-05
期刊：
影响因子：
--
通讯作者：
E. Spargo;I. Everall;P. Lantos
中科院分区：
文献类型：
--
作者：
E. Spargo;I. Everall;P. Lantos
海马体通常在原发性痴呆中受到影响，病理改变可能很严重。然而，关于HIV感染和亨廷顿舞蹈病（HD）的海马病理学知识却非常有限。在11名HIV感染患者和9名HD患者中，使用了一种立体技术（光学“定向器”）来评估海马体四个区域的神经元群。HIV患者死亡时无机会性感染或脑肿瘤；他们患有艾滋病毒脑炎或轻微的变化。所有HD病例均经临床诊断，家族史阳性，并表现出尾状核特征性病变。将神经元计数与9个对照组进行比较。在齿状体、CA3和CA4颗粒细胞层，三组间神经元数量密度无显著差异。在CA1区域，HIV组和HD组之间存在显著差异。HD患者CA1区的神经元数值密度显著低于HIV患者和对照组(平均（SD） 37.5 (5.0)；70.1 (13.4);57.9 （15.4） × 10(3) / mm3, p < 0.001（学生t检验）。这一差异代表神经元损失了35%。在所有四个海马体区域中，HIV组的神经元密度都高于对照组，但差异并不显著，这可以用对照组的平均年龄更高来解释。这些发现有助于理解艾滋病和亨廷顿氏病痴呆的机制。
The hippocampus is usually affected in primary dementias and the pathological changes may be severe. Knowledge of hippocampal pathology in HIV infection and Huntington's disease (HD), however, is extremely limited. A stereological technique (the optical "disector") has been used to assess neuronal populations in four areas of the hippocampus in 11 patients with HIV infection and in nine patients with HD. The HIV patients died without opportunistic infections or neoplasms affecting the brain; they had HIV encephalitis or minimal changes. The HD cases were all clinically diagnosed, had a positive family history and showed the characteristic lesions in the caudate nucleus. The neuronal counts were compared with those in nine controls. In the granule cell layer of the dentate, CA3 and CA4, there was no significant difference in the neuronal numerical density between the three groups. A striking difference between the HIV and HD groups was seen in the CA1 region. The neuronal numerical density in the CA1 area was significantly lower in the HD patients than in either the HIV patients or the controls (mean (SD) 37.5 (5.0); 70.1 (13.4); 57.9 (15.4) x 10(3) per mm3, p < 0.001 (Students' t test)). This difference represents a neuronal loss of 35%. In all four hippocampal areas the neuronal density was higher in the HIV group than in the controls but the differences were not significant and can be explained by the higher average age of the control group. These findings contribute to the understanding of the mechanism of dementia in both AIDS and in Huntington's disease.